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Journal of Medical Sciences
  Year: 2014 | Volume: 14 | Issue: 4 | Page No.: 192-200
DOI: 10.3923/jms.2014.192.200
 
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25-Hydroxyvitamin D3 Level in Patients with Chronic Viral Hepatitis B

Mohammed Amin Mohammed, Nesreen Moustafa Omar, Amany H. Mansour, Sherin Mohamed Abd El-Aziz and Gamal Othman

Abstract:
Vitamin D is an important immune modulator that has an emerging role in inflammatory and metabolic liver diseases. An association has been established between low levels of vitamin D and several adverse health outcomes including upper respiratory and enteric infections, viral hepatitis and HIV infections. It exerts protective effects during infections by up-regulating the expression of cathelicidin and β-defensin 2 in phagocytes and epithelial cells. Thus, vitamin D appears to have systemic antimicrobial effects that may be crucial in a variety of both acute and chronic illnesses. In the current study, 25-hydroxyvitamin D3 (25-OHD3) levels were compared among 75 patients with chronic hepatitis B virus infection (Group I), sixty naturally immunized individuals (Group II) and another sixty age and sex-matched healthy controls. Routine biochemical parameters like hepatitis markers, hepatitis B virus serology, hepatitis B virus DNA, 25-OHD3 and Parathormone levels were measured. Patients in group I had a significantly lower 25-OHD level compared with group II and controls (13.9±4.93 vs. 22.1±6.14 and 23.15±8.28 ng mL-1, respectively p<0.001). In contrast, patients in group I had a higher parathyroid hormone level compared with group II and control group (103.14±24.5 vs. 75.14±23.4 and 74.1±20.15 pg mL-1, respectively p<0.001). Also, 25-OHD levels were inversely correlated with hepatitis B virus DNA levels. The observed diminished 25-OHD levels in patients infected with hepatitis B virus may be an indicator of the viral replication status and portends a poor prognosis.
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How to cite this article:

Mohammed Amin Mohammed, Nesreen Moustafa Omar, Amany H. Mansour, Sherin Mohamed Abd El-Aziz and Gamal Othman, 2014. 25-Hydroxyvitamin D3 Level in Patients with Chronic Viral Hepatitis B. Journal of Medical Sciences, 14: 192-200.

DOI: 10.3923/jms.2014.192.200

URL: https://scialert.net/abstract/?doi=jms.2014.192.200

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