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Journal of Medical Sciences

Year: 2013 | Volume: 13 | Issue: 6 | Page No.: 432-438
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Authors

M.I. Amar

I.Y. Adam Shama

A.A. Enaia

A.E.O. Hind

A.M. Hager

Keywords

Research Article

Effects of Various Levels of Oral Doses Dexamethasone (Al-nagma) Abused as Cosmetic by Sudanese Women on Wistar Rats

M.I. Amar, I.Y. Adam Shama, A.A. Enaia, A.E.O. Hind and A.M. Hager
Dexamethasone (locally known as Al-Nagma) is used as anti-inflammatory drug for different types of inflammatory diseases. Sudanese women abuse this drug as cosmetic for gaining weight and whiten skin, without care of the side effects. The present study aims to evaluate the toxicity of low (60 μg/kg/day) and high doses (180 μg/kg/day) of Dexamethasone on kidney and liver of Wistar rats and to estimate the effect of abuse in normal individual. The rats were randomly classified into three groups, each group contain six rats. Group one (control) received distilled water. Group two treated with low dose (60 μg/kg/day) and group three treated with high dose (180 μg/kg/day). To achieve the objective of this study, the body weight was measured before and after treatment, sodium, potassium, glycated hemoglobin and other Haematological parameters were also measured. Dexamethasone significantly decreased the body weight of Wistar rats treated with low and high dose (22.8±7.4, 19.9±8.3), respectively compared with control group (32.7±9). In addition, there is a significant difference in sodium and HbA1c levels in both groups treated with the dexamesathone. In contrast potassium significantly decreased in both groups when compared with control group. Also pathological changes in fatal organs demonstrated as lesions in liver and kidneys, fatty cytoplasmic vaculation and necrosis of the hepatocytes, glomerular alteration, packing, dilatation, fatty change and necrosis. This study concluded that, Dexamethasone abuse decreased the body weight, rather than believed by Sudanese women. It causes hyperglycemia and hypertension affecting renal function.
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