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Journal of Medical Sciences
  Year: 2012 | Volume: 12 | Issue: 8 | Page No.: 274-279
DOI: 10.3923/jms.2012.274.279
 
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Evaluation of Analgesic, Neuropharmacological and Anti-diarrheal Potential of Jatropha gossypifolia (Linn.) Leaves in Mice

Apurba Sarker Apu, Kazi Ireen, Shakhawat Hossan Bhuyan, Maima Matin, Md. Faruq Hossain and Farhana Rizwan

Abstract:
The aim of the study was to evaluate the possible analgesic, neuropharmacological and anti-diarrheal activities of methanol extract of leaves of Jatropha gossypifolia Linn. (Euphorbiaceae) in mice. Acetic acid induced writhing inhibition test was used to measure the analgesic activity of the extract. The neuropharmacological activity of the extract was assessed by hole cross, hole board and elevated plus-maze tests and the anti-diarrheal activity was evaluated by castor oil induced diarrhea inhibition test. The extract demonstrated highly significant (p<0.001) analgesic activity with % inhibitions of writhing response at doses 200 and 400 mg kg-1 b.wt. were 67.56 and 65.14%, respectively. In hole cross test, the extract at both doses showed significant (p<0.05) sedative effect in mice. In hole board test, the extract showed highly significant (p<0.001) anxiolytic activity at dose 200 mg kg-1 b.wt. whereas, the same activity was observed at dose 400 mg kg-1 b.wt. in elevated plus-maze test. The extract also showed highly significant (p<0.001) anti-diarrheal activity in castor oil induced diarrhea inhibition test. The present findings suggest that the plant possess significant analgesic, neuropharmacological and anti-diarrheal properties and could be a prominent source of medicinally importance phytoconstituents.
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How to cite this article:

Apurba Sarker Apu, Kazi Ireen, Shakhawat Hossan Bhuyan, Maima Matin, Md. Faruq Hossain and Farhana Rizwan, 2012. Evaluation of Analgesic, Neuropharmacological and Anti-diarrheal Potential of Jatropha gossypifolia (Linn.) Leaves in Mice. Journal of Medical Sciences, 12: 274-279.

DOI: 10.3923/jms.2012.274.279

URL: https://scialert.net/abstract/?doi=jms.2012.274.279

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