Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Journal of Medical Sciences
  Year: 2007 | Volume: 7 | Issue: 4 | Page No.: 526-535
DOI: 10.3923/jms.2007.526.535
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Some Biochemical Changes in Serum and Synovial Fluid of Patients with Rheumatoid Arthritis
Amany Zayed, Hager Amer , Hala Nasar , Atef Ibrahiem and Hesham Mottawie

Abstract: Sixty cases were included in this study, divided into 2 groups; Group I (Control) (n = 20) and Group II (RA) (n = 40). Estimation of VEGF levels in serum (VEGFBL) and in synovial fluid aspirates of Knee joint in 11 RA patients (VEGFSF) using ELISA, in addition to different acute phase reactants and indices of disease activity. Plain x-ray of both hands to detect juxta-articular osteopenia and erosions. Serum VEGF showed a highly significant difference between Group I (Control) (165.4±46 pg mL-1) and Group II (RA) (886.3±267.8 pg mL-1) (p = 0.000). Serum CRP showed a highly significant difference between Group I (Control) and Group II (RA) (p = 0.000). Serum VEGF showed significant correlation with VEGF in Synovial Fluid (p = 0.012), Articular Index (AI) (p = 0.04), ESR (p = 0.01), Alkaline Phosphatase (ALKPASE) (p = 0.04) and CRP (p = 0.00, highly significant correlation). VEGF levels in synovial fluids (88.7±17.3 pg mL-1) showed a significant correlation with VEGF in serum (VEGFBL) (p = 0.012) of the same RA patients, WBCs (p = 0.02) and CRP (p = 0.00, highly significant correlation). Serum VEGF is higher in RA patients than in controls. VEGF appears to play an active part in joint inflammation in early RA, however, in long-standing RA elevated VEGF serum levels may be an independent mark.
PDF Fulltext XML References Citation Report Citation
How to cite this article:

Amany Zayed, Hager Amer , Hala Nasar , Atef Ibrahiem and Hesham Mottawie , 2007. Some Biochemical Changes in Serum and Synovial Fluid of Patients with Rheumatoid Arthritis. Journal of Medical Sciences, 7: 526-535.

DOI: 10.3923/jms.2007.526.535

URL: https://scialert.net/abstract/?doi=jms.2007.526.535
COMMENT ON THIS PAPER
 
 
 

 
  Bullet Navigation
 
  Page Icon Online First
  Page Icon Current Issue
  Page Icon Previous Issues
  Page Icon Editorial Board
  Page Icon Submit a Manuscript
  Page Icon Guide to Authors
  Page Icon Subscribe to E-alerts

  Bullet Indexed In
 
  Page Icon ASCI-Database
  Page Icon Asian Digital Library
  Page Icon EMBASE
  Page Icon Google Scholar
  Page Icon SCIMAGO

Science Alert
Curve Bottom