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Journal of Medical Sciences
  Year: 2005 | Volume: 5 | Issue: 4 | Page No.: 253-259
DOI: 10.3923/jms.2005.253.259
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Effects of Cerastes cerastes gasperettii Venom on Hepatocyte Mitochondria Ultrastructure and Blood Cells Count

M.K. Al-Sadoon and A.S.A. Haffor

The purpose of this study was to examine the effects of Cerastes cerastes Venom (CCV) on hepatocyte mitochondria pathological changes and blood cell counts. Thirty three rats were divided randomly into three groups Negative Control (NC), Positive Control (PC) and treatment. The positive control group was injected intraperitoneally saline for 8 days whereas the experimental group was injected intraperitoneally crude CCV, at a dose of ¼ LD50, for the same period. All animals of the three groups were kept under normal laboratory and dietary conditions. The hepatocyte ultrastructure examination showed mitochondria swelling associated with a reduction in the cristae and dilution of the inner and outer membranes. Frequent mitochondria rapid division was noted that led to hyperplasia. Dilatation of smooth endoplasmic reticulum, hypertrophied kuffer cell associated with eosinophil infiltration and lipid accumulation were also observed. In comparison with the NC group there was a significant (p<0.05) increase in WBC and PLT whereas RBC, Hb and HCT decreased significantly (p<0.05) in the experimental group. As compared to the PC group all these measures were increased in the experimental group. The overall regression of Hb on RBC was significant (R2=0.85). These results suggest that CCV contains biochemical factors that activated WBC proliferation and inhibit platelet aggregation. Long term exposure to CCV is related to hepatocyte mitochondria membrane and cristae dilutions and their subsequent deactivation of respiratory chain enzymes.
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How to cite this article:

M.K. Al-Sadoon and A.S.A. Haffor , 2005. Effects of Cerastes cerastes gasperettii Venom on Hepatocyte Mitochondria Ultrastructure and Blood Cells Count. Journal of Medical Sciences, 5: 253-259.

DOI: 10.3923/jms.2005.253.259






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