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Journal of Medical Sciences
  Year: 2005 | Volume: 5 | Issue: 3 | Page No.: 212-215
DOI: 10.3923/jms.2005.212.215
 
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Serum Steroid Levels in Mice Infected with Plasmodium berghei berghei

C.A. Adejuwon and A.O. Adejuwon

Abstract:
Serum levels progesterone and testosterone were measured by radioimmunoassay (RIA) in female and male mice infected with Plasmodium berghei berghei, respectively and in uninfected female and uninfected male mice correspondingly. The mean SEM serum progesterone (nmol L-1) of 2.41±0.31 in infected female mice is lower than 3.45±0.44 observed in uninfected mice. The mean SEM serum testosterone (nmol L-1) of 2.24±0.2 in infected male mice is significantly higher than 1.39±0.14 observed in uninfected mice. The results provide evidence to suggest that malaria parasite Plasmodium berghei berghei lowers peripheral levels of progesterone in female mice. However, it appears to increase peripheral levels of testosterone in male mice. Malaria is known to be an endemic disease of the tropics. In females, the actions of progesterone as an antagonist to both sodium retaining and potassium losing effect of adrenal steroids could be affected. Raised levels of testosterone in males during infection could possibly reduce the risk of aplastic anaemia in the young approaching puberty.
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How to cite this article:

C.A. Adejuwon and A.O. Adejuwon , 2005. Serum Steroid Levels in Mice Infected with Plasmodium berghei berghei. Journal of Medical Sciences, 5: 212-215.

DOI: 10.3923/jms.2005.212.215

URL: https://scialert.net/abstract/?doi=jms.2005.212.215

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