
	Journal of Medical Sciences
	Year: 2001 \| Volume: 1 \| Issue: 5 \| Page No.: 320-323 DOI: 10.3923/jms.2001.320.323

Antimicrobial activity and Cytotoxicity of Clerodane Diterpines from Polyalthia longifolia seed

Anwarul Islam, Abu Sayeed, Golam Sadik, M. Motiur Rahman and G. R. M. Astaq Mohal Khan

Abstract: Two clerodane diterpines viz., Kolavenic acid (1) and 16-oxo-cleroda-3, 13(14) E-diene-15-oic acid (2) were isolated from the petroleum ether (C₂H₅-O-C₂H₅) extract of the seed of Polyalthia longifolia and were screened against fourteen pathogenic bacteria for their antibacterial activities. The test materials exhibited strong activities against most of the test bacteria. The minimum inhibitory concentration (MIC) of the compound (1) and (2) was determined against Bacillus cereus, Bacillus subtilis, Escherichia coli, Shigella flexneriae and Shigella boydii which were 64, 64, 32, 16 and 32μg ml^-1for compound (1) and 16, 32, 8, 4 and 16 μg ml^-1 for compound (2), respectively. The cytotoxic activity of the compound (1) and (2) was determined by brine shrimp lethality bioassay. Both the compounds showed significant cytotoxic activities and LC₅₀ values of Kolavenic acid (1) and 16-oxo-cleroda-3, 13(14)E-diene-15-oic acid (2) were 3.16 and 2.52μg ml^-1, respectively.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Effects of Field Treatments on Barley Seed Sensitivity to Organic Seed Sanitation (Hot Water)

•	Chemical Constituents and Cytotoxic Activity of Polyalthia cauliflora var. cauliflora

How to cite this article:

Anwarul Islam, Abu Sayeed, Golam Sadik, M. Motiur Rahman and G. R. M. Astaq Mohal Khan, 2001. Antimicrobial activity and Cytotoxicity of Clerodane Diterpines from Polyalthia longifolia seed. Journal of Medical Sciences, 1: 320-323.

DOI: 10.3923/jms.2001.320.323

URL: https://scialert.net/abstract/?doi=jms.2001.320.323

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Asian Digital Library
		EMBASE
		Google Scholar

Science Alert