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Journal of Medical Sciences

Year: 2001 | Volume: 1 | Issue: 4 | Page No.: 224-227
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Authors

Alam Khan

Shahmim Akhter

Muhammad Mohsin Siddiqui

M. Muzaffar Ali Khan

Gul Nawab

Keywords

Effect of age, sex and seasons on the concentration of thyroid hormones (T3 and T4) and thyroid stimulating hormone (TSH) was studied in 25237 thyroid patients who were referred to the radioimmunoassay (RIA) laboratory of the Institute of Radiotherapy and Nuclear Medicine (IRNUM), Peshawar during 1984-1990 (except 1987) and 1995-1996. T3 and T4 of all of these patients were determined by RIA and TSH was determined by immuno-radiometric assay (IRMA). The difference in mean concentration of T3, T4 and TSH in infants and children was non-significant at p<0.05. Comparing all age groups together, higher mean concentration of T3 was found in old age group followed by infants, adults and children. Similarly, the mean concentration of T4 was higher in old age group followed by adults, infants and children. While higher mean values for TSH were observed in infants followed by children, adult and old age group. The infants and children were having significantly higher values of TSH than the old age group and adults at p< 0.05. Concentration of T3 and T4 was significantly higher (p<0.05) in females than males, while TSH concentration was not significantly different (P>0.05) in both sexes. Mean concentration of T3 in summer and autumn was significantly higher than the other seasons and mean concentration of T4 in winter and summer was higher. The mean concentration of TSH in spring and autumn was significantly higher than the mean concentration of TSH in winter and summer at p<0.05.
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