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Research Journal of Microbiology
  Year: 2011 | Volume: 6 | Issue: 7 | Page No.: 609-617
DOI: 10.3923/jm.2011.609.617
Prevalence and Antimicrobial Susceptibility Pattern of Extended Spectrum β-Lactamases Producing Escherichia coli in Diabetic Foot Infection
Sevanan Murugan, Jayanthi , Pongiya Uma Devi and Peedikayil Neetu John

Abstract:
To study the prevalence of Extended Spectrum Beta Lactamases producing E. coli among diabetic foot ulcer patients attending the tertiary care hospitals and diabetic centers in South India. Thirty four isolates of E. coli were obtained from 106 patients. These isolates were subjected to susceptibility testing as per Clinical and Laboratory Standards Institute guidelines. They were further screened for ESBL (Extended Spectrum Beta Lactamases) production by screening test, double disc approximation test and National Committee for Clinical Laboratory Standards Confirmatory test respectively. Of the 34 isolates of E. coli, 14 (4%) were found to be ESBL producer. E. coli exhibited 100% susceptibility to imipenem and meropenem and resistant to cephalexin, erythromycin, gentamicin and norfloxacin. Intermediate resistance was observed only against cefotaxime (76.5%). High %age of resistance to amikacin (52.9%), gentamicin (64.7%), cloxacillin (70.6%), co-trimoxazole (76.5%) and cephalexin (82.4%) were observed among ESBL producers. These findings suggests that prospective multicenter studies are required to assess the appropriate empirical antibiotic requirements in diabetic foot ulcers taking into consideration the etiology of ulcers.
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How to cite this article:

Sevanan Murugan, Jayanthi , Pongiya Uma Devi and Peedikayil Neetu John, 2011. Prevalence and Antimicrobial Susceptibility Pattern of Extended Spectrum β-Lactamases Producing Escherichia coli in Diabetic Foot Infection. Research Journal of Microbiology, 6: 609-617.

DOI: 10.3923/jm.2011.609.617

URL: https://scialert.net/abstract/?doi=jm.2011.609.617

 
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