Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Journal of Applied Sciences
  Year: 2013 | Volume: 13 | Issue: 5 | Page No.: 729-735
DOI: 10.3923/jas.2013.729.735
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Satureja khuzestanica Extract Elicits Antinociceptive Activity in Several Model of Pain in Rats

Arezoo Saberi, Gholamreza Sepehrib, Saeed Esmaeili-Mahani, Bahram Rasoulian, Vahid Sheibani, Khadije Esmaeilpour, Zahra Hajializadeh and Elham Abbasloo

Abstract:
Satureja khuzistanica is used as anti-inflammatory, antinociceptive and antiseptic in folk medicine; however, its analgesic effects have not yet been clarified in different scientific models of pain. The Objective of this work was to determine the antinociceptive activity of Satureja khuzistanica and possible involvement of opioid system in several model of pain in rats. All experiments were carried out on male Wistar rats. The tail-flick, hot-plate and acid acetic tests were used to assess the antinociceptive effect of Satureja khuzistanica Extract (SKE). The extract was given at doses of 12, 25, 50 and 100 mg kg-1 intraperitoneally (i.p.). Naloxone (3 mg kg-1) was used to evaluate the opioid receptor involvement in SKE antinociceptive effects. The data showed that SKE caused a dose-dependent analgesic effect on tail-flick, hot-plate and acid acetic tests. The Maximum antinociceptive activity of Satureja extract was observed 30 min after the injection of 100 mg kg-1 and significantly persisted up to 45 min. Blockage of opioid receptors by naloxone (3 mg kg-1) could not prevent SKE-induced analgesic effect. In addition, SKE could potentiate the antinociceptive effect of 5 mg kg-1 morphine on tail-flick test. Co-administration of 12 mg kg-1 SKE with 3 mg kg-1 morphine produced potent antinociceptive effects which were greater than those in morphine-treated or SKE group (p<0.001). Our results indicate that SKE has analgesic property in several models of pain and it can be used for the treatment and/or management of painful conditions.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    An Update on Pharmacology of Satureja Species; From Antioxidant, Antimicrobial, Antidiabetes and Anti-hyperlipidemic to Reproductive Stimulation
How to cite this article:

Arezoo Saberi, Gholamreza Sepehrib, Saeed Esmaeili-Mahani, Bahram Rasoulian, Vahid Sheibani, Khadije Esmaeilpour, Zahra Hajializadeh and Elham Abbasloo, 2013. Satureja khuzestanica Extract Elicits Antinociceptive Activity in Several Model of Pain in Rats. Journal of Applied Sciences, 13: 729-735.

DOI: 10.3923/jas.2013.729.735

URL: https://scialert.net/abstract/?doi=jas.2013.729.735

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 

Curve Bottom