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Journal of Applied Sciences
  Year: 2013 | Volume: 13 | Issue: 4 | Page No.: 595-601
DOI: 10.3923/jas.2013.595.601
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Effect of L-Arginine on Some Biochemical Markers of Metabolic Syndrome Associated with Brain Function in Female Wistar Rats

A.C.C. Egbuonu and L.U.S. Ezeanyika

Metabolic syndrome (Mes) was associated with insulin resistance and endothelial dysfunction. In particular, endothelial dysfunction was associated with a significant reduction in nitric oxide, a metabolite of L-arginine (Arg). Insulin resistance occurs following the failure of insulin to maintain glucose balance or regulate appetite via signaling in the brain. Thus, this study investigated the influence of Arg on some biochemical markers of Mes associated with the brain function and on the brain histology of female Wistar rats. Two groups of rats (n = 8) were exposed to a single dose of 60 mg kg-1 b.wt. of Arg and 3 ml kg-1 b.wt. of distilled water respectively as treated and control groups. Exposure was per oral (p.o) for twenty eight consecutive days. Exposure to Arg evoked a significant increase (p<0.01) in aspartate amino transferase (AST) activity (24.95±0.10 IU L-1) and ammonium ion (NH4+) concentration (39.58±0.16 μg mL-1) in the rats’ serum. It increased (p<0.01) the aspartate amino transferase to alanine amino transferase (AST:ALT) ratio (0.37±0.01) of the rats. Brain section of Arg-treated rats revealed degeneration, characterized by necrosis, oedema and reduction of astrocytes. AST:ALT ratio had a significant positive correlation (r = 0.01) with AST activity and NH4+ concentration. The results suggest Arg-induced adverse influence on the studied markers of Mes associated with the brain function. Hence, exposure to Arg may impair the brain function and possibly, worsen Mes related to brain function of the rats.
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  •    Biochemical Effects of Pesticides on Serum and Urinological System of Rats
  •    Preventive Effect of Bridelia ferruginea Against High-fructose Diet Induced Glucose Intolerance, Oxidative Stress and Hyperlipidemia in Male Wistar Rats
  •    L-arginine Exposure Improves Renal Function Markers of Metabolic Syndrome in Female Rats
  •    Sub-chronic Concomitant Ingestion of L-arginine and Monosodium Glutamate Improves Feed Efficiency, Lipid Metabolism and Antioxidant Capacity in Male Wistar Rats
How to cite this article:

A.C.C. Egbuonu and L.U.S. Ezeanyika, 2013. Effect of L-Arginine on Some Biochemical Markers of Metabolic Syndrome Associated with Brain Function in Female Wistar Rats. Journal of Applied Sciences, 13: 595-601.

DOI: 10.3923/jas.2013.595.601






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