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Journal of Applied Sciences
  Year: 2004 | Volume: 4 | Issue: 3 | Page No.: 472-476
DOI: 10.3923/jas.2004.472.476
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Modified Venezuelan Kaolin as Possible Antacid Drug

Carlos F. Linares, Laura Afonso and Marcos Rosa- Brussin

A Venezuelan clay conformed mainly by kaolin was modified hydrothermically using sodium carbonate solutions at different concentrations: 0.5, 1.0, 1.5 and 2.0 M. The synthesized solids were characterised using different techniques such as: X ray diffraction (XRD), infrared (FT-IR) and BET surface area to determine the textural properties from original and modified clay. Finally, all solids were tested in the presence of synthetic gastric juice (HCl + pepsin) to determine its neutralization capacity. The results showed that modified clays were more active than original clay. The activities of these modified materials increase, when the concentration in sodium carbonate with which these materials were treated, is increased. On the other hand, it was observed a small interaction among the modified clays and pepsin molecule; this interaction was also determined to a commercial compound with antacid properties. The interaction was related to the adsorption of pepsin molecule on the surface of solids, which do not change its chemical properties. These new antacid materials are interesting because they can be very cheap and effective.
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How to cite this article:

Carlos F. Linares, Laura Afonso and Marcos Rosa- Brussin, 2004. Modified Venezuelan Kaolin as Possible Antacid Drug. Journal of Applied Sciences, 4: 472-476.

DOI: 10.3923/jas.2004.472.476






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