Synthesis of Certain New 6-Iodoquinazolines as Potential Antitubercular Agents


	Journal of Applied Sciences
	Year: 2004 \| Volume: 4 \| Issue: 2 \| Page No.: 302-307 DOI: 10.3923/jas.2004.302.307

Synthesis of Certain New 6-Iodoquinazolines as Potential Antitubercular Agents

S.M. Mosaad, K.I. Mohammed, M.A. Ahmed and S.G. Abdel-Hamide

Abstract: In the present study 2-(4-Chlorophenyl)-6-iodo-3, 4-dihydroquinazolin-4-one 3 was prepared by the reaction of 2-(4-chlorophenyl)-6-iodo-4H-3,1-benzoxazin-4-one 2 with formamide. Treatment of 3 with phosphorus penta sulfide yielded the thione derivative 4. Alkylation of 3 and 4 with certain alkylhalides gave the target compounds. The structure of the new compounds was confirmed by ¹H NMR, IR and MS. Some of the new compounds were screened for antitubercular activity, the 4-alkylthio derivatives were active while the 4-alkyloxy derivatives were inactive.

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How to cite this article:

S.M. Mosaad, K.I. Mohammed, M.A. Ahmed and S.G. Abdel-Hamide, 2004. Synthesis of Certain New 6-Iodoquinazolines as Potential Antitubercular Agents. Journal of Applied Sciences, 4: 302-307.

DOI: 10.3923/jas.2004.302.307

URL: https://scialert.net/abstract/?doi=jas.2004.302.307

COMMENTS

23 April, 2009
Sunayana Gajare:
A very good paper

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