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Journal of Applied Sciences
  Year: 2004 | Volume: 4 | Issue: 2 | Page No.: 302-307
DOI: 10.3923/jas.2004.302.307
Synthesis of Certain New 6-Iodoquinazolines as Potential Antitubercular Agents
S.M. Mosaad, K.I. Mohammed, M.A. Ahmed and S.G. Abdel-Hamide

Abstract:
In the present study 2-(4-Chlorophenyl)-6-iodo-3, 4-dihydroquinazolin-4-one 3 was prepared by the reaction of 2-(4-chlorophenyl)-6-iodo-4H-3,1-benzoxazin-4-one 2 with formamide. Treatment of 3 with phosphorus penta sulfide yielded the thione derivative 4. Alkylation of 3 and 4 with certain alkylhalides gave the target compounds. The structure of the new compounds was confirmed by 1H NMR, IR and MS. Some of the new compounds were screened for antitubercular activity, the 4-alkylthio derivatives were active while the 4-alkyloxy derivatives were inactive.
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How to cite this article:

S.M. Mosaad, K.I. Mohammed, M.A. Ahmed and S.G. Abdel-Hamide, 2004. Synthesis of Certain New 6-Iodoquinazolines as Potential Antitubercular Agents. Journal of Applied Sciences, 4: 302-307.

DOI: 10.3923/jas.2004.302.307

URL: https://scialert.net/abstract/?doi=jas.2004.302.307

COMMENTS
23 April, 2009
Sunayana Gajare:
A very good paper
 
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