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International Journal of Pharmacology

Year: 2015 | Volume: 11 | Issue: 5 | Page No.: 414-422
Research Article

Anti-Obesity Effects of Extracts from Sulfur-Grain Maggot In Obesity Model Rats

Sang- Oh Park
Institute of Animal Resources, Kangwon National University, Chuncheon Gangwondo, 200-701, Republic of Korea
Byung- Sung Park
Devision of Applied Animal Science, Kangwon National University, Chuncheon Gangwondo, 200-701, Republic of Korea
This research tried to explain only a part of mechanisms possibly involved in anti-obesity effects of the Extracts of Sulfur-grain Maggot (ESM). Animals were classified into a normal diet group (NC, normal control), HFD (high-fat diet without ESM), HFD 15 (high-fat diet+oral administration of 15 mg of ESM extract/100 g body weight) and HFD 30 (high-fat diet+oral administration of 30 mg of ESM extract/100 g body weight). The body weight gain declined in HFD 15 and HFD 30 groups compared with the HFD group, even though the diet intake increased significantly. The weight of liver and adipose tissue decreased significantly in HFD 15 and 30 groups compared with the control HFD. Triglyceride, total cholesterol, low density lipoprotein-cholesterol (LDL-C) and Atherogenic Index (AI) decreased in HFD 15 and HFD 30 groups compared with in the HFD group, but the contents of high density lipoprotein-cholesterol (HDL-C) increased significantly. Expression of sterol regulatory element binding proteins (SREBP-1α, SREBP-2)-mRNA in the liver was decreased in HFD 15 and 30 groups compared with the control HFD but the expression of lipoprotein lipase (LPL) and peroxisome proliferator-activated receptors(PPARα)-mRNAin adipose tissue increased significantly. Fat accumulation in the liver tissues and liver damage were greatly reduced in HFD 15 and HFD 30 groups compared with the HFD group. In conclusion, this research discovered for the first time that grain maggot has anti-obesity effects, by reducing the abdominal fat of obese model animals and lowering blood lipid level through the down-regulation of SREBP-1α, SREBP-2 and the up-regulation of LPL-mRNA, not only PPARα-mRNA.
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