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International Journal of Osteoporosis and Metabolic Disorders
  Year: 2011 | Volume: 4 | Issue: 1 | Page No.: 1-14
DOI: 10.3923/ijom.2011.1.14
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Tocotrienols as an Anti-Osteoporotic Agent: The Progress So Far

A.S. Nazrun, M. Norazlina, M. Norliza and S. Ima Nirwana

Osteoporosis is a metabolic bone disease affecting both men and women especially postmenopausal women. Osteoporosis has been associated with oxidative stress and therefore the protective effects of antioxidants such as vitamin E were studied. Lately, there has been a growing interest in tocotrienol, a potent vitamin E with anti-cholesterol, anti-cancer and perhaps anti-osteoporotic properties. We have conducted studies on the effects of tocotrienol on various animal models of osteoporosis and discovered its ability to prevent osteoporosis. In most of the studies, tocotrienol mixtures as well as its isomers such as gamma-, alpha- or delta-tocotrienol were compared to alpha tocopherol, the most abundant and widely commercialized vitamin E. The techniques that were used included Enzyme-linked immunosorbent assay (ELISA), bone histomorphometry, Dual energy X-ray absorptiometry (DEXA) and biomechanical testing. Most of the results revealed that tocotrienols were more efficacious than alpha-tocopherol in protecting the bone from various inducers of osteoporosis. These convincing results warrant further studies in pursuing the idea that in future, tocotrienol would be accepted as part of the treatment regime for osteoporosis. The role of tocotrienols in studies using various osteoporotic models was discussed in light of its potential as an anti-osteoporotic agent.
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  •    Effect of Dietary Tocotrienols on Antioxidant Status and Low Density Lipoprotein Oxidation in Rats, Exposed to Cigarette Smoke
  •    Effect of Tocotrienol on Lipid Peroxidation in Experimental Gastritis Induced by Restraint Stress
  •    Tocotrienols and α-Tocopherol Reduced Acute and Chronic Lung Lipid Peroxidation Induced by Paraquat in Rats
How to cite this article:

A.S. Nazrun, M. Norazlina, M. Norliza and S. Ima Nirwana, 2011. Tocotrienols as an Anti-Osteoporotic Agent: The Progress So Far. International Journal of Osteoporosis and Metabolic Disorders, 4: 1-14.

DOI: 10.3923/ijom.2011.1.14





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