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International Journal of Cancer Research

Year: 2007 | Volume: 3 | Issue: 2 | Page No.: 119-126
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Authors

Ramachandran Venugopal

Palaniyandi Senthilnathan

Venkatraman Magesh

Balasubramanian Rajkapoor

Dhanapal Sakthisekaran

Keywords

The present study was conducted to ascertain the chemotherapeutic efficacy of Solanum trilobatum when administered along with paclitaxel against experimental lung carcinogenesis. Healthy male Swiss albino mice (6-8 weeks old) were treated with Benzo (a) pyrene (50 mg kg-1 body weight) to induce lung cancer. Paclitaxel at a dose of 33 mg kg-1 body weight intraperitoneally and Solanum trilobatum 200 mg kg-1 body weight orally was administrated for four weeks to lung cancer bearing animals. The level of lipid peroxides (LPO) was found to be markedly increased in carcinogen-administered animals, in contrast the activities/levels of the antioxidant status both in lung and liver were decreased in carcinogen administered animals. Upon Solanum trilobatum along with Paclitaxel administration the above pathological changes were bring back to near normal. From these findings we have concluded that Solanum trilobatum when administered along with paclitaxel prevents LPO and protects antioxidant system strongly aganist Benzo(a)pyrene induced lung cancer.
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How to cite this article

Ramachandran Venugopal, Palaniyandi Senthilnathan, Venkatraman Magesh, Balasubramanian Rajkapoor and Dhanapal Sakthisekaran, 2007. Chemotherapeutic Efficacy of Solanum trilobatum along with Paclitaxel in Lung Cancer Bearing Swiss Albino Mice. International Journal of Cancer Research, 3: 119-126.

DOI: 10.3923/ijcr.2007.119.126

URL: https://scialert.net/abstract/?doi=ijcr.2007.119.126

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