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International Journal of Cancer Research
  Year: 2006 | Volume: 2 | Issue: 4 | Page No.: 415-419
DOI: 10.3923/ijcr.2006.415.419
Combination of XRCC1, GSTM1 and GSTT1 Genetic Polymorphisms and Susceptibility to Male Breast Cancer
Leila Kohan , Shahpour Omidvari and Mostafa Saadat

Abstract:
Male breast cancer is an uncommon disease that has been the focus of limited research. In the present study, we specifically investigated whether combination of common genetic variants in the X-ray repair cross-complementation group 1 gene (XRCC1; exon 10, codon 399 Arg/Gln and exon 6, codon 194 Arg/Trp) and loss-of-function deletion polymorphisms in glutathione S-transferases T1 (GSTT1) and M1 (GSTM1), were associated with an altered risk of male breast cancer. Blood samples from 10 males with breast cancer and 15 age- and sex-matched healthy persons were collected. The GSTM1, GSTT1 and XRCC1 genotypes were determined using PCR-based method. The null genotypes of GSTM1 and GSTT1 and 399Gln and 194Trp alleles of XRCC1 assumed as high-risk genotypes and alleles. Statistical analysis showed that the χ2 for linear trend for 0, 1, 2 and 3 putative high-risk genotypes is equal to 5.673 (p = 0.017).
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How to cite this article:

Leila Kohan , Shahpour Omidvari and Mostafa Saadat , 2006. Combination of XRCC1, GSTM1 and GSTT1 Genetic Polymorphisms and Susceptibility to Male Breast Cancer. International Journal of Cancer Research, 2: 415-419.

DOI: 10.3923/ijcr.2006.415.419

URL: https://scialert.net/abstract/?doi=ijcr.2006.415.419

 
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