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International Journal of Biological Chemistry

Year: 2010 | Volume: 4 | Issue: 1 | Page No.: 10-18
Research Article

Telfairia occidentalis Ameliorates Oxidative Brain Damage in Malnorished Rats

A.A.A. Kayode
Biochemistry Unit, Department of Chemical Sciences, College of Natural and Applied Sciences, Bells University of Technology, Ota, Ogun State, Nigeria
O.T. Kayode
Biochemistry Unit, Department of Chemical Sciences, College of Natural and Applied Sciences, Bells University of Technology, Ota, Ogun State, Nigeria
A.A. Odetola
Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Nigeria
It has been observed and established that enhancing the antioxidant defense system during the early phase of rehabilitation is important to the survival of wasting protein energy malnourished patients. In this study, comparison was made between the efficacy of dietary protein replenishment and supplementation with Telfairia occidentalis leaves, in the treatment of oxidative brain damage in the malnourished rats. The protein energy malnourished rats were produced by feeding weanling rats a protein deficient diet (2% protein) for 28 days. The malnourished rats were then divided into three dietary treatment groups, 20% protein+10% T. occidentalis group (PTG), 20% Protein Group (PG) and the 10% T. occidentalis group (TG). Significant decrease in brain size (p<0.01), activity of superoxide dismutase (p<0.01), catalase (p<0.01) and increased Malondialdehyde levels (p<0.01), indicative of oxidative damage were observed in the malnourished rats as compared with the control group. Reduced level of oxidative damage was however observed in group TG, PG and PTG , respectively. The result indicates that T. occidentalis leaves supplementation with protein repletion is more effective for recovery from protein energy malnutrition induced oxidative damage in rats than protein repletion alone.
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How to cite this article

A.A.A. Kayode, O.T. Kayode and A.A. Odetola, 2010. Telfairia occidentalis Ameliorates Oxidative Brain Damage in Malnorished Rats. International Journal of Biological Chemistry, 4: 10-18.

URL: https://scialert.net/abstract/?doi=ijbc.2010.10.18

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