Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
International Journal of Biological Chemistry
  Year: 2008 | Volume: 2 | Issue: 2 | Page No.: 42-48
DOI: 10.3923/ijbc.2008.42.48
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
Hepatoprotective Effect of Leaf Extracts of Parkinsonia aculeataL. Against CCl4 Intoxication in Albino Rats
S.W. Hassan, R.A. Umar, A.A. Ebbo, A.J. Akpeji and I.K. Matazu

Abstract:
Hepatoprotective activity of 50% ethanolic leaf extracts of Parkinsonia aculeata was evaluated against carbon tetrachloride (CCl4)-induced hepatic damage in rats. The extract at doses of 100, 200 and 300 mg kg-1 body weight were administered orally once daily. Hepatoprotective activity was measured based on biochemical parameters. Significantly (p<0.05) elevated levels of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total bilirubin (TB) and peroxide value in CCl4-intoxicated rats were restored to normal levels in the animals treated with the extract at doses of 100, 200 and 300 mg kg-1 and CCl4. The levels of total proteins, albumin, vitamins C and E appreciated significantly (p<0.05) in animals treated with different doses of the leaf extracts and CCl4. The effects were dose-dependant. These results suggest the leaf extracts of this plant to have potential therapeutic and preventive efficacies, probably due to its antioxidative effect.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Soy Diet Diminish Oxidative Injure and Early Promotional Events Induced by CCl4 in Rat Liver
  •    Parkinsonia aculeata: A Phytopharmacological Review
  •    Octreotide: A Somatostatin Analogue, Protects Liver against CCl4-Induced Liver Injury in Mouse Model
How to cite this article:

S.W. Hassan, R.A. Umar, A.A. Ebbo, A.J. Akpeji and I.K. Matazu, 2008. Hepatoprotective Effect of Leaf Extracts of Parkinsonia aculeataL. Against CCl4 Intoxication in Albino Rats. International Journal of Biological Chemistry, 2: 42-48.

DOI: 10.3923/ijbc.2008.42.48

URL: https://scialert.net/abstract/?doi=ijbc.2008.42.48

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 

       

       

Curve Bottom