Synthesis and Anticonvulsant Activity of Novel Substituted Phenyl Indoloimidazole Derivatives

Research Article

Synthesis and Anticonvulsant Activity of Novel Substituted Phenyl Indoloimidazole Derivatives

N. Kumar, P.K. Sharma, V.K. Garg and P. Singh

A number of new N-1-phenyl-3-substituted phenyl indolo (2, 3) imidazole derivatives were synthesized and evaluated for their anticonvulsant activity. The titled compounds were obtained by condensing different aromatic aldehyde with N-1-phenyl isatin in presence of ammonium acetate and glacial acetic acid. All the newly synthesized compounds were screened for their anticonvulsant activity using maximal electroshock seizure method taking diazepam as standard drug. Among the synthesized compounds, compound 1b and 1c showed highly significant anticonvulsant activity and could be considered as leads for further investigations.

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N. Kumar, P.K. Sharma, V.K. Garg and P. Singh, 2011. Synthesis and Anticonvulsant Activity of Novel Substituted Phenyl Indoloimidazole Derivatives. Current Research in Chemistry, 3: 114-120.

DOI: 10.3923/crc.2011.114.120

URL: https://scialert.net/abstract/?doi=crc.2011.114.120

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Authors

N. Kumar

P.K. Sharma

V.K. Garg

P. Singh

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Research Article

Synthesis and Anticonvulsant Activity of Novel Substituted Phenyl Indoloimidazole Derivatives

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