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Asian Journal of Plant Sciences
  Year: 2021 | Volume: 20 | Issue: 2 | Page No.: 355-362
DOI: 10.3923/ajps.2021.355.362
 
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Ameliorative Effects of Taraxacum officinale Crude Extracts on Paclitaxel Induced-Haematological Toxicity and Oxidative Stress

Promise Madu Emeka , Haya Mohammed Almofarfesh, Sulafa Abdulla Alsahlawi and Hany Aly Hassan Mohammad

Abstract:
Background and Objective: Paclitaxel (PTX) is an effective anticancer agent but in the same fashion, has a major dose-limiting haematological toxicity. Taraxacum officinale (TXO) crude extract has been used in the treatment of anaemia in herbal remedies. Here, this study evaluated the possible attenuation of PTX-induced haematological adverse effects and lipid peroxidation with coadministration of TXO crude extract. Materials and Methods: The whole plant of TXO was soaked in water for 24 hrs, filtered, and evaporated to dryness with rotary evaporator. Five groups of 6 adult rats weighing between 150-160 g were used. Normal saline was administered to control group 1, group 2 was given 30 mg kg1 of PTX alone intraperitoneally. Group 3 and 4 were given PTX 30 mg kg1 followed by 200 and 400 mg kg1 TXO respectively. The fifth group received 200 mg kg1 TXO alone. Drug administration lasted for 10 days after which animals were sacrificed and blood collected for differential analysis. Significant (p<0.001) weight losses in PTX treated group and were attenuated by coadministration of TXO. Results: Group treated with TXO alone showed a significant (p<0.001) weight gain. Non-significant decreases in RBC counts, haemoglobin and haematocrit were observed with PTX alone, which were increased with the addition of TXO. Results also showed significant (p<0.05) decreases in WBC, neutrophil and platelet counts by PTX were also attenuated by co-administration with TXO. Increased lipid peroxidation by PTX was significantly reduced as well. Conclusion: This study has demonstrated that TXO crude extract has the potential to attenuate PTX-induced haematological adverse effects in rats, an anticancer drug frequently used in the treatment of many cancers.
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How to cite this article:

Promise Madu Emeka, Haya Mohammed Almofarfesh, Sulafa Abdulla Alsahlawi and Hany Aly Hassan Mohammad, 2021. Ameliorative Effects of Taraxacum officinale Crude Extracts on Paclitaxel Induced-Haematological Toxicity and Oxidative Stress. Asian Journal of Plant Sciences, 20: 355-362.

DOI: 10.3923/ajps.2021.355.362

URL: https://scialert.net/abstract/?doi=ajps.2021.355.362

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