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American Journal of Drug Discovery and Development

Year: 2013 | Volume: 3 | Issue: 3 | Page No.: 166-173
Research Article

Effect of Momordica dioica Roxb. Fruits on Pentylentetrazole Induced Convulsions and Oxidative Stress in Mice

P. Satish Kumar
Department of Pharmacology, Vaagdevi College of Pharmacy, Kakatiya University, Hanamkonda, Warangal, Andhra Pradesh, India
B.S. Sharvanabhava
Department of Pharmacology, Vaagdevi College of Pharmacy, Kakatiya University, Hanamkonda, Warangal, Andhra Pradesh, India
K. Sainath Reddy
Anurag Group of Institutions, School of Pharmacy, Jawaharlal Nehru Technological University, Jodimetla, Hyderabad, Andhra Pradesh, India
B. Rajitha
Anurag Group of Institutions, School of Pharmacy, Jawaharlal Nehru Technological University, Jodimetla, Hyderabad, Andhra Pradesh, India
E. Venkateshwarlu
Department of Pharmacology, Vaagdevi College of Pharmacy, Kakatiya University, Hanamkonda, Warangal, Andhra Pradesh, India
LiveDNA: 91.27358
The main objective of the study is to evaluate anticonvulsant and antioxidative effect of Ethanolic extract of Momordica dioica fruits in mice. The effect of alcoholic extract of Momordica dioica Roxb. fruits on convulsions induced using Pentylentetrazole, changes in Acetyl cholinesterase (AchE) activity, Levels of Glutamate and GABA were studied using standard procedures. Markers of oxidative stress such as Malondialdehyde, Glutathione reductase, Superoxide dismutase and catalase were evaluated in mice using standard procedure. The ethanolic extract of Momordica dioica Roxb. increased duration of onset of convulsions (p<0.001), decreased the levels of AchE, glutamate (p<0.001) and increased the levels GABA (p<0.001) in brain as compared with disease control group. A marked effect on oxidative parameters such that lower MDA levels (p<0.01), increased levels of GSH, SOD, Catalase (p<0.001) were estimated comparing to disease group. From the study it has been proved that the plant extract showed anticonvulsant and antioxidative effect.
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