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Asian Journal of Dermatology
  Year: 2011 | Volume: 3 | Issue: 1 | Page No.: 20-24
DOI: 10.3923/ajd.2011.20.24
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Langerhans Cells Could Migrate via Vein

K. Sugiura and M. Sugiura

The aim of this study is to investigate other route for LCs migration. Generally, Langerhans Cells (LCs) capture some antigens, then LCs migrate from the skin and present antigen to T cells in the lymph nodes. The priority route of LCs migration is via lymph vessels. If some of LCs migrates via veins, some of these cells could go to other organs, for instance, lung. We have investigated human cutaneous tissue, seborrheic keratosis by hematoxylin-eosin and immunohistochemical studying for the relation between LCs and seborrheic keratosis. We used 3-step ABC technique for CD83 and S-100 staining and LSAB technique for CD1a. We observed many s-100 and CD1a positive LCs were in the epidermis, some of these were CD83 positive cells in the vein of the dermis. One of them was passing through the valve of the vein. This was a CD83 positive cell. Present findings supported that some LCs could migrate via vein vessels. Both skin and lung have been in contact with the outside world and could have common information about antigen. Some LCs in the vein might migrate to the lung and present some information about antigens to T cells in the lung. We concluded that the route of LCs migration is not only via lymph vessels but also via the veins.
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How to cite this article:

K. Sugiura and M. Sugiura, 2011. Langerhans Cells Could Migrate via Vein. Asian Journal of Dermatology, 3: 20-24.

DOI: 10.3923/ajd.2011.20.24






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