|
|
| |
Sub-chronic Study of Aqueous Stem Bark Extract of Senna siamea in Rats |
|
A. Mohammed,
S.B. Mada and H.M. Yakasai |
Abstract:
Senna siamea is a plant commonly used in traditional medicine to treat
hypertension, malaria and diabetes mellitus. The aim of this study was to investigate
the sub-chronic toxicity of aqueous extract from the stem bark of S. siamea
male Wistar rats. The extract was orally administered for seven weeks at 200,
400, 800 and 1600 mg kg-1 body weight. The results obtained showed
that the extract significantly (p<0.05) increases the body weight and feed
intake of the rats. Hematological parameters (PCV, Hb, platelets, WBC and RBC)
were not significantly (p<0.05) affected by the extract. But the levels of
serum liver enzymes (Alkaline Phosphatase (ALP), Alanine Aminotransaminase (ALT),
Aspartate Aminotransaminase (AST) were significantly different (p<0.05) from
the normal control group. In contrast, no significant change was observed in
the total protein and albumin levels in the treated group compared to the normal
group. Similarly, serum glucose, triglycerides, cholesterol and the markers
of kidney function (creatinine, urea, potassium, sodium and chloride) did not
differ significantly (p<0.05) from the normal control group. The quantitative
determination of saponins, alkaloids, total polyphenolics and flavonoids in
(g/g) were found to be 0.07±0.01, 0.05±0.02, 0.92±0.05
and 0.06±0.01. These results may explain the use of S. siamea stem
bark in folk medicine due its less toxic effect.
|
|
|
PDF
Fulltext
XML
References
Citation
Report Citation
|
|
|
How to cite this article:
A. Mohammed, S.B. Mada and H.M. Yakasai, 2012. Sub-chronic Study of Aqueous Stem Bark Extract of Senna siamea in Rats. Asian Journal of Biological Sciences, 5: 314-321.
DOI: 10.3923/ajbs.2012.314.321
URL: https://scialert.net/abstract/?doi=ajbs.2012.314.321
|
|
|
|
|
| COMMENT ON THIS PAPER |
|
|
|
|
| |
 |
Navigation |
| |
|
|
| |
|
Indexed In |
| |
|
|
Subscribe Today 
