Potential Value of ICAM-1 as a Biomarker for Detection of Progression and Prognosis in Breast Carcinoma


	American Journal of Biochemistry and Molecular Biology
	Year: 2017 \| Volume: 7 \| Issue: 2 \| Page No.: 91-95 DOI: 10.3923/ajbmb.2017.91.95

Potential Value of ICAM-1 as a Biomarker for Detection of Progression and Prognosis in Breast Carcinoma

Nabila Abd El Maksoud, Halla Mohamed Ragab

, HebatAllah Mohamed Shaaban, Samah Mohamed Radwan, Wafaa Abd Elaziz and Nesreen Hassan Hafez

Abstract: Background and Objective: Breast cancer is reported as one of the most frequent type of cancer all over the world and its incidence is increasing. Tumorigenesis and its progression to metastatic disease are accompanied by changes in the expression of Cell Adhesion Molecules (CAMs). The intercellular adhesion molecule-1 (ICAM-1) is expressed on the surface of a wide variety of cells which are intimately involved in inflammatory reactions and progression of tumor. To date, no serum biomarkers can discriminate benign from malignant breast lesions, this study aimed to identify the role of ICAM-1 using enzyme linked immunosorbant assay (ELISA) as a biomarker in breast cancer and study whether it could be used in assessment of progression of tumor. Materials and Methods: Serum ICAM-1 was determined in 92 women diagnosed as primary breast carcinoma (mean age, 49.04±12.67 years, range, 26-76 years) compared with 25 benign breast disease cases. Results: Data showed that ICAM-1 were higher in primary breast cancer than in benign tumor but the difference did not reach the significant level (p = 0.771). A significant elevation was observed in concentration of ICAM-1 in patients more than 50 years old (p = 0.05). Moreover, ICAM-1 concentration did not differ based on clincopathological parameters. Conclusion: Serum levels of ICAM-1 seem to be not associated with tumor burden, histological type, grade, size and hormonal receptors status in patients with breast cancer. So serum ICAM-1 is not a useful marker for diagnosis of breast cancer in Egyptian patients.

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How to cite this article:

Nabila Abd El Maksoud, Halla Mohamed Ragab, HebatAllah Mohamed Shaaban, Samah Mohamed Radwan, Wafaa Abd Elaziz and Nesreen Hassan Hafez, 2017. Potential Value of ICAM-1 as a Biomarker for Detection of Progression and Prognosis in Breast Carcinoma. American Journal of Biochemistry and Molecular Biology, 7: 91-95.

DOI: 10.3923/ajbmb.2017.91.95

URL: https://scialert.net/abstract/?doi=ajbmb.2017.91.95

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