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Asian Journal of Biochemistry
  Year: 2015 | Volume: 10 | Issue: 2 | Page No.: 67-77
DOI: 10.3923/ajb.2015.67.77
 
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Sub-Chronic Oral Esculetin (6, 7-Dihydroxy-Coumarin) Exposure in Male Wistar Rats: Effect on Some Serum Functions and Organ Histology
Cemaluk C. Egbuonu Anthony, Ambrose E. Ogbu and Lawrence U.S. Ezeanyika

Abstract:
The study assessed the effect on some serum functions and organ histology following esculetin exposure in rats. Five groups (n = 6) of Wistar rats respectively received (A) 6.0 mg kg-1 body weight (b.wt.), (B) 12.0 mg kg-1 b.wt. (C) 24.0 mg kg-1 b.wt. of esculetin, (D, vehicle control) 0.2 mL kg-1 b.wt. of 10% dimethylsulfoxide, DMSO and (E, normal control) 0.2 mL kg-1 b.wt. of Distilled Water (DW) per orally and daily for 28 days. On comparison with the controls, a dose dependent and significant (p<0.05) decrease in the concentration of serum sodium ion (141.00±5.02 mmol L-1) but an increase in that of potassium ion (9.39±3.24 mmol L-1) was observed in the group C rats. The decrease in the serum protein concentration (6.58±0.77 mmol L-1) in the group C rats, though dose dependent, was not significant (p>0.05). In the group C rats, the decrease (p<0.05) in the serum urea concentration (10.95±0.61 mmol L-1) was dose dependent but the increase (p<0.05) in the serum creatinine concentration (85.87±8.31 mmol L-1) was not dose dependent. Histological examination revealed a severely dilated hepatic vein (A) and proliferated cells around the bile canaliculi (B) in group C rats. Other organs examined (kidney, testis, brain and heart) did not show any lesion in the test groups. The results showed that the esculetin-induced improvement in the serum parameters might not alter the studied organ histology in the rats, especially at the lower tested concentrations.
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How to cite this article:

Cemaluk C. Egbuonu Anthony, Ambrose E. Ogbu and Lawrence U.S. Ezeanyika, 2015. Sub-Chronic Oral Esculetin (6, 7-Dihydroxy-Coumarin) Exposure in Male Wistar Rats: Effect on Some Serum Functions and Organ Histology. Asian Journal of Biochemistry, 10: 67-77.

DOI: 10.3923/ajb.2015.67.77

URL: https://scialert.net/abstract/?doi=ajb.2015.67.77

 
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