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Asian Journal of Biochemistry

Year: 2007 | Volume: 2 | Issue: 6 | Page No.: 437-440
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Authors

M. Firoozrai

H. Mehrabi

A. Ehsani

M. Najafi

M. Ghaffari

Keywords

Research Article

Activities of Anti-Oxidative Enzymes, Catalase and Glutathione Reductase in Red Blood Cells of Patients with Coronary Artery Disease

M. Firoozrai, H. Mehrabi, A. Ehsani, M. Najafi and M. Ghaffari
Free radical scavenging enzymes are an important part of body anti-oxidative system. The aims of this study were to evaluate the enzymatic activities of anti-oxidative enzymes of erythrocytes, catalase (CAT) and Glutathione Reductase (GR), that might be indicators of protective mechanisms involved in atherosclerosis and also to evaluate the serum lipids and lipoproteins which are thought to be correlated with these two anti oxidative enzymes. The study population consisted of 90 patients with angiographically proved coronary stenosis in surgery section of Tehran Rajaee cardiovascular center and 30 subjects without any coronary heart disease used as control. Glutathione reductase and catalase activities in erythrocytes were assayed. Patients had not significantly decreased glutathione reductase activity compared to that in control subjects. However the catalase activity was significantly decreased in erythrocytes of the atherosclerotic patient. Atherosclerotic smoking patients had similar catalase activity compared to that in nonsmoking patients. However the glutathione reductase activity was lower in erythrocytes of the atherosclerotic smoking patients. No significant correlations were found between serum lipids and two anti-oxidative enzymes activities in patients and control subjects.
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