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Asian Journal of Biochemistry

Year: 2007 | Volume: 2 | Issue: 6 | Page No.: 375-385
Research Article

Antitumor Activity of Urtica pilulifera on Ehrlich Ascites Carcinoma in Mice

M. Abdel-Kader
Department of Biochemistry, Faculty of Agriculture, Cairo University, Egypt
A.H. Mahmoud
Department of Medicinal Chemistry, Faculty of Agriculture, Cairo University, Egypt
H.M. Motawa
Department of Pharrnacognosea, Faculty of Agriculture, Cairo University, Egypt
H.E. Wahba
Department of Cultivation and Production of Medicinal and Aromatic Plants, Egypt
A.Y. Ebrahim
Department of Cultivation and Production of Medicinal and Aromatic Plants, Egypt
The anti-tumor activity of 20% methanol extract of Urtica pilulifera was evaluated against the Ehrlich Ascites Carcinoma tumor model in mice. The activity was assessed using hematological studies, solid tumor mass and survival time. Intraperitoneal injection of Urtica pilulifera crude extract with different doses increased the survival time. Hematological parameters and packed cell volume, which were altered by tumor inoculation, were restored. Solid tumor mass was also significantly reduced. The bioactive compounds which produced these activities were isolated and identified as flavonoids and phenolic acids.
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