Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Asian Journal of Biochemistry
  Year: 2006 | Volume: 1 | Issue: 4 | Page No.: 307-315
DOI: 10.3923/ajb.2006.307.315
Quantitative Structure Activity Relationships of Some Selective Inhibitors of Glucagon Receptor: A Hansch Approach
C. Karthikeyan , P. Manoj Kumar , N.S. Hari Narayana Moorthy , S.K. Shrivastava and Piyush Trivedi

Abstract:
A quantitative structure activity analysis based on linear free energy related approach of Hansch was attempted on a series of glucagon receptor inhibitory triaryl imidazoles. Substituent constants are used to characterize the effect of structural modification on aromatic ring A and B of triaryl imidazole derivatives on glucagon receptor inhibition. The statistically significant correlations deduced by multiple linear regression analysis suggest that steric property of the substituents in aromatic ring B governs the glucagon receptor binding of triaryl imidazoles. The hydrogen acceptor atoms in the aromatic ring B is shown to have a positive influence on the active site binding of triaryl imidazoles whereas the hydrogen acceptor atoms in the aromatic ring A appears to have a negative effect on the inhibitory potency of triaryl imidazoles. Additionally, the study also indicates that bulky substituent in aromatic ring B confers selectivity for glucagon receptor over p38 mitogen activated protein kinase enzyme.
 [Fulltext PDF]   [Fulltext HTML]   [XML: Abstract + References]   [References]   [View Citation]  [Report Citation]
 RELATED ARTICLES:
  •    2D Qsar Study of 7-Methyljuglone Derivatives: An Approach to Design Anti Tubercular Agents
  •    Quantitative Structure Activity Relationship Analysis of N-(mercaptoalkanoyl)- and [(acylthio)alkanoyl] Glycine Derivatives as ACE Inhibitors
How to cite this article:

C. Karthikeyan , P. Manoj Kumar , N.S. Hari Narayana Moorthy , S.K. Shrivastava and Piyush Trivedi , 2006. Quantitative Structure Activity Relationships of Some Selective Inhibitors of Glucagon Receptor: A Hansch Approach. Asian Journal of Biochemistry, 1: 307-315.

DOI: 10.3923/ajb.2006.307.315

URL: https://scialert.net/abstract/?doi=ajb.2006.307.315

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 

Curve Bottom