• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. Asian Journal of Animal and Veterinary Advances
  2. Vol 8 (3), 2013
  3. 483-492
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

Asian Journal of Animal and Veterinary Advances

Year: 2013 | Volume: 8 | Issue: 3 | Page No.: 483-492
DOI: 10.3923/ajava.2013.483.492

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 202

Authors


S. Buhari

Country: Malaysia

H. Kalthum

Country: Malaysia

Y.M. Goh

Country: Malaysia

S.H. Gan

Country: Malaysia

Keywords


  • ovariohysterectomy
  • Tramadol
  • anesthesia
  • pharmacokinetic
Research Article

Influence of Surgery on the Pharmacokinetics of Tramadol Following Intravenous Administration in Dogs

S. Buhari, H. Kalthum, Y.M. Goh and S.H. Gan
Surgery and anesthesia causes fluctuations in hemodynamics which can lead to subtherapeutic drug levels and usually therapeutic failure, making postsurgical pain management difficult. The influence of surgery and anesthesia on the pharmacokinetics of intravenous tramadol in dogs was investigated. Tramadol (3 mg kg-1) was administered during premedication to female dogs (n = 6) undergoing ovariohysterectomy (Group 1) and to another non-surgery group (n = 6) of female dogs (Group 2) and the pharmacokinetics were compared between the groups. The outcome of this study showed that surgery and anesthesia affected the pharmacokinetics of tramadol, as indicated by a two-fold increase in the elimination half-life (1.10±0.18 h in Group 1 compared to 0.49±0.07 h in Group 2) and a three-fold increase in the area under the curve (770.21±117.76 ng.h mL-1 for Group 1 compared to 117.61±85.16 ng.h mL-1 for Group 2). Clearance was also significantly lower (3.98±0.56 mL min-1 kg-1) in Group 1 than in Group 2 (21.06±9.34 mL kg-1). Serum levels of both interleukin-6 and β-endorphin were increased at 6 and 9 h in the surgery group which further indicates that the rapid metabolism and clearance of tramadol in dogs are correlated with postsurgical pain. Therefore, re-administration of tramadol at 3 h is necessary for pain control. This suggests that surgery has a significant effect on the pharmacokinetics of tramadol in dogs.
PDF Fulltext XML References Citation

How to cite this article

S. Buhari, H. Kalthum, Y.M. Goh and S.H. Gan, 2013. Influence of Surgery on the Pharmacokinetics of Tramadol Following Intravenous Administration in Dogs. Asian Journal of Animal and Veterinary Advances, 8: 483-492.

DOI: 10.3923/ajava.2013.483.492

URL: https://scialert.net/abstract/?doi=ajava.2013.483.492

Related Articles

Efficacy of Diclofenac Sodium, Either Alone or Together with Cefotaxime Sodium, for Control of Postoperative Pain, in Dogs Undergoing Ovariohysterectomy

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved