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Asian Journal of Applied Sciences
  Year: 2019 | Volume: 12 | Issue: 4 | Page No.: 180-184
DOI: 10.3923/ajaps.2019.180.184
Evaluation of Antidiabetic Effects of Saponins Extracted from Methanol Leaf Extract of Commiphora kerstingii Engl.
Yerima Musa and Yusuf Ibrahim Alkali

Abstract:
Background and Objective: About 80% of population of developing countries relies exclusively on plants to meet their health care needs, according to World Health Organization. This study aimed to further investigate the hypoglycemic activity of saponins extracted from the leaf of Commiphora kerstingii. Materials and Methods: Hyperglycaemia was induced by single intraperitoneal injection of alloxan and high dose fructose administration. Acute oral LD50 of the fraction in rats was conducted according to the method described by Lorke. Results: The oral LD50 of the extract was found to be 1,352 mg kg1. The extract lowered the Blood Glucose Level (BGL) in the 3 doses used (100, 200 and 400 mg kg1) and was significant at p<0.02 for the 400 mg kg1 dose after the 8th, 16th and 24th h. The saponin-rich portion of the methanol leaf extract of Commiphora kerstingii Engl. significantly lowered elevated BGL in the experimental animal models. Conclusion: The saponin extracted from the methanol leaf extract of Commiphora kerstingii showed antidiabetic activity in the experimental models employed at the doses used.
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How to cite this article:

Yerima Musa and Yusuf Ibrahim Alkali, 2019. Evaluation of Antidiabetic Effects of Saponins Extracted from Methanol Leaf Extract of Commiphora kerstingii Engl.. Asian Journal of Applied Sciences, 12: 180-184.

DOI: 10.3923/ajaps.2019.180.184

URL: https://scialert.net/abstract/?doi=ajaps.2019.180.184

 
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