Hamed ReihaniKermani
Department of Neurosurgery,
Neuroscience Research Center,
Kennan University of
Medical Sciences, Kennan, Iran
Mohsen Soltani Gerd Faramarzi
Department of Neurosurgery, Neuroscience Research Center,
Kerman University of Medical Sciences, Kennan, Iran
Mehdi Ansari
Department of Neurosurgery, Neuroscience Research Center,
Kerman University of Medical Sciences, Kennan, Iran
Alireza Ghafarinejad
Department of Neurosurgery, Neuroscience Research Center,
Kerman University of Medical Sciences, Kennan, Iran
ABSTRACT
The aim of investigation was to determine interleukin-6 (IL-6; a proinflammatory cytokine) and IL-10 (an anti-inflammatory cytokine) concentrations in cerebrospinal fluid (CSF) of Idiopathic Intracranial Hypertension patients (IIH). The study covered 28 middle aged female (IIH patients, n = 14; controls, n = 14). CSF IL-6 and IL-10 concentration were determined by the use of commercial enzyme-linked immunosorbent assay (ELISA) kits. Concentration of IL-6 and IL-10 in CSF of IIH patients was 23.6±3.46 pg mL 1 and 3.7±0.5 pg mL 1 and in controls was 1.8±1.9 and 4.0±1.0 pg mL 1, respectively. Elevated IL-6 concentration in IIH patients found to be statistically significant in comparison to controls (p<0.05). There was no significant difference of IL-10 in IIH and controls. Role of immune system and inflammatory processes in etiology and pathogenesis of IIH must be taking into account.
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How to cite this article
Hamed ReihaniKermani, Mohsen Soltani Gerd Faramarzi, Mehdi Ansari and Alireza Ghafarinejad, 2008. Cerebrospinal Fluid Concentration of Interleukin-6 and Interleukin-10 in Idiopathic Intracranial Hypertension. Journal of Medical Sciences, 8: 205-208.
DOI: 10.3923/jms.2008.205.208
URL: https://scialert.net/abstract/?doi=jms.2008.205.208
DOI: 10.3923/jms.2008.205.208
URL: https://scialert.net/abstract/?doi=jms.2008.205.208
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