Bulent Gunduz
Department of Biology,
Faculty of Arts and Sciences,
Abant Izzet Baysal University Bolu, 14280, TURKEY
ABSTRACT
The research work was conducted to investigate the effects of melatonin on streptozotocin (STZ)-induced diabetes in mice. Mice were divided into six groups. The first two groups were STZ injected animals. The other four groups, were STZ plus melatonin injected. The melatonin doses were 50 or 500µg kg-1 respectively. Plasma glucose level, body weights and insulates were examined. The plasma glucose levels were significantly higher only in STZ-injected mice. No significant difference was seen in the plasma glucose content of STZ plus melatonin 50 and 500µg kg-1 groups. Mononuclear cell infiltration of pancreatic islets (insulates) was much more intensive only in STZ injected mice.These results suggested that when melatonin is injected at the same time with STZ, it acts to prevent the development of diabetes in experimental mice.
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How to cite this article
Bulent Gunduz, 2001. Protective Effect of Melatonin on Streptozotocin-induced Diabetes in Mice. Journal of Medical Sciences, 1: 117-120.
DOI: 10.3923/jms.2001.117.120
URL: https://scialert.net/abstract/?doi=jms.2001.117.120
DOI: 10.3923/jms.2001.117.120
URL: https://scialert.net/abstract/?doi=jms.2001.117.120
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