K. B. Mirbahar
Department of Animal Reproduction, Faculty of A. H. and Veterinary Sciences, Sindh Agriculture University, Tandojam, Pakistan
W.N. McDonell
Department of Animal Reproduction, Faculty of A. H. and Veterinary Sciences, Sindh Agriculture University, Tandojam, Pakistan
P. Eyre
Department of Animal Reproduction, Faculty of A. H. and Veterinary Sciences, Sindh Agriculture University, Tandojam, Pakistan
ABSTRACT
Airway hyper-reactivity to histamine was studied in horses with respiratory disease (n=7) and in normal horses (n=4) selected on the basis of physical and laboratory examination. The animals were challenged with aerosolised histamine and the lung function was measured. The normal horses were sensitised to Ascaris suum and then challenged again with the same dose of histamine. The response of the same horse to the same dose of histamine before and after sensitisation were compared between themsevles and with diseased horses which suggested that the abnormal horses were hyper-reactive to histamine when compared to normal horses in which the reactivity to histamine was significantly were hyper-reactive to histamine when compared to the normal horses in which the reactivity to histamine was significantly greater after sensitisation. The response of normal horses after sensitisation to A. suum, resembled more with the abnormal group than with their own response before sensitisation. They studied suggest the presence of hyper-reactivity in horses suffering from respiratory disease and also suggest that hyper-reactivity can be induced in horses with experimental sensitisation.
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K. B. Mirbahar, W.N. McDonell and P. Eyre, 2000. Airway hyper-reactivity to histamin in clinically abnormal and experimentally sensitised horses. Pakistan Journal of Biological Sciences, 3: 2188-2192.
DOI: 10.3923/pjbs.2000.2188.2192
URL: https://scialert.net/abstract/?doi=pjbs.2000.2188.2192
DOI: 10.3923/pjbs.2000.2188.2192
URL: https://scialert.net/abstract/?doi=pjbs.2000.2188.2192
REFERENCES
- Boushey, H.A., M.J. Holtzman, J.R. Sheller and J.A. Nadel, 1980. State of art: Bronchial hyperreactivity. Am. Rev. Respiratory Dis., 121: 389-413.
Direct Link - Cook, W.R. and P.D. Rossdale, 1963. Respiratory distress in some diseases of man and animals. The syndrome of broken Wind in the horse. Proc. Royal Soc. Med., 56: 972-977.
PubMedDirect Link - Derksen, F.J., R.F. Slocombe and N.E. Robinson, 1982. Pulmonary effects of intravenous histamine in the conscious pony: Dose-response relationships and reproducibility. Am. J. Vet. Res., 43: 2134-2137.
Direct Link - Hargreave, F.E., G. Ryan, N.C. Thomson, P.M. O'Byrne, K. Latimer, E.F. Juniper and J. Dolovich, 1981. Bronchial responsiveness to histamine or methacholine in asthma: Measurement and clinical significance. J. Allergy Clin. lmmunol., 68: 347-355.
CrossRefDirect Link - Jorres, A., D. Nowak, H. Magrussen, P. Speckin and S. Coschyk, 1996. The effect of ozone exposure on allergen responsiveness in subjects with asthma or rhinitis. Am. J. Respiratory Crit. Care Med., 153: 56-64.
CrossRefPubMedDirect Link - Lowell, F.C., 1964. Observations on heaves. An asthma-like syndrome in the horse. J. Allergy, 35: 322-330.
CrossRefDirect Link - McLaughlin, R.F., W.S. Tyler and R.O. Canada, 1961. Subgross pulmonary anatomy in various mammals and man. J. Am. Med. Assoc., 175: 694-697.
CrossRefDirect Link - McPherson, E.A., G.H.K. Lawson, J.R. Murphy, J.M. Nicholson, J.A. Fraser, R.G. Breeze and H.M. Pirie, 1978. Chronic obstructive pulmonary disease (COPD): Identification of affected horses. Equine Vet. J., 10: 47-53.
CrossRefDirect Link - McPherson, E.A. and J.R. Thomson, 1983. Chronic obstructive pulmonary disease in the horse 1: Nature of the disease. Equine Vet. J., 15: 203-206.
CrossRefDirect Link - Mirbahar, K.B. and P. Eyre, 1982. Autacoid and autonomic reactivity of sheep lung parenchymal strip and its modification by antigenic sensitization. Int. J. Immunopharmacol., 4: 533-539.
CrossRefDirect Link - Mirbahar, K.B., W.N. McDonell, W. Bignell and P. Eyre, 1985. Effects of aerosolized histamine and carbachol in the conscious horse. Can. J. Comp. Med., 49: 211-216.
Direct Link - Mirbahar, K.B., W.N. McDonell and P. Eyre, 2000. Effect of aerosol Ascaris suum challenge in the horse. Pak. J. Biol. Sci., 3: 1724-1729.
CrossRefDirect Link - Morcillo, E.J., M. Perpina and J. Esplugues, 1984. Hyperresponsiveness to autacoids and autonomic drugs in lung parenchymal strips from sensitized guinea pigs. Am. Rev. Respiratory Dis., 129: 948-951.
CrossRefDirect Link - Obel, N.J. and C.G. Schmiterlow, 1948. The action of histamine and other drugs on the bronchial tone in horses suffering from alveolar emphysema (heaves). Basic Clin. Pharmacol. Toxicol., 4: 71-80.
CrossRefDirect Link - Shishikura, T., M. Yamada, K. Oguro, N. Tamaki and T. Kosugi, 1989. Induction of airway hyperresponsiveness in allergic rats. Int. J. Tissue Reactions, 12: 341-346.
PubMed - Tarayre, J.P., M. Aliaga, M. Barbara, N. Malfetes, S. Vieu and J. Tisne-Versailles, 1991. Bronchial inflammation and hyperreactivity after anaphylactic shock in guinea pigs actively sensitized by systemic or aerosol route. Methods Find. Exp. Clin. Pharmacol., 13: 93-97.
PubMed - Tesarowski, D.B., L. Viel and W.N. McDonell, 1996. Pulmonary function measurements during repeated environmental challenge of horses with recurrent airway obstruction (heaves). Am. J. Vet. Res., 57: 1214-1219.
PubMed - Willoughby, R.A. and W.N. McDonell, 1979. Pulmonary function testing in horses. Vet. Clin. North Am. Large Anim. Practice, 1: 171-196.
Direct Link