Subscribe Now Subscribe Today
Abstract
Fulltext PDF
References
Research Article
 

Studies on the Antibacterial Effect of Different Fractions of Curcuma longa Against Urinary Tract Infection Isolates



Nadia Gul , Talat Y. Mujahid , Nayyar Jehan and Samia Ahmad
 
ABSTRACT

Curcuma longa belongs to the family Zingiberaceae, commonly known as turmeric. Antibacterial activity of ionic, oil, resins and ethanolic fractions of turmeric was checked against both gram positive and gram negative Urinary Tract Infection isolates. Sixty-five bacterial strains were isolated from urine of patients suffering from urinary tract infection and identified by conventional methods. Eighty percent of total isolated organisms were found to be gram negative while remaining 20% were gram positive. Ionic, resin and ethanolic fractions of turmeric were found to possessed antibacterial activity against S. saprophyticus, S. aureus, S. epidermidis, S. pyogenes, E. faecalis and B. subtilis while oil fraction exhibited no activity against the same organisms. No activity of any of the four fractions was found against gram negative isolates. The antibacterial activity of turmeric was also compared with fifteen standard antibiotics. Comparative study of turmeric fractions with standard antibiotics showed that ionic, resin and ethanolic fractions of turmeric are 100% effective against all tested gram positive organisms, which are resistant to most of the broad-spectrum antibiotics used.

Services
Related Articles in ASCI
Similar Articles in this Journal
Search in Google Scholar
View Citation
Report Citation

 
  How to cite this article:

Nadia Gul , Talat Y. Mujahid , Nayyar Jehan and Samia Ahmad , 2004. Studies on the Antibacterial Effect of Different Fractions of Curcuma longa Against Urinary Tract Infection Isolates. Pakistan Journal of Biological Sciences, 7: 2055-2060.

DOI: 10.3923/pjbs.2004.2055.2060

URL: https://scialert.net/abstract/?doi=pjbs.2004.2055.2060

REFERENCES
Ali, N.S., 2000. Protocol for evaluation and management of urinary tract infection in adults. Pak. J. Med. Sci. Rev., 16: 251-254.

Ammon, H.P.T. and M.A. Wahl, 1991. Pharmacology of Curcuma longa. Planta Med., 57: 1-7.
CrossRef  |  PubMed  |  Direct Link  |  

Barthelemy, S., L. Vergnes, M. Moynier, D. Guyot, S. Labidalle and E. Bahraoui, 1998. Curcumin and curcumin derivatives inhibit Tat-mediated transactivation of type 1 human immunodeficiency virus long terminal repeat. Res. Virol., 149: 43-52.
CrossRef  |  Direct Link  |  

Baum, I. and A. Ng, 2004. Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models. J. Alzheimers Dis., 6: 367-377.
CrossRef  |  Direct Link  |  

Caughey, B., L.D. Raymond, G.J. Raymond, L. Maxson, J. Silveira and G.S. Baron, 2003. Inhibition of protease-resistant prion protein accumulation in vitro by curcumin. J. Virol., 77: 5499-5502.
CrossRef  |  PubMed  |  Direct Link  |  

Chirangini, P., G.H. Sharma and S.K. Sinha, 2004. Sulfur free radical reactivity with curcumin as reference for evaluating antioxidant properties of medicinal zingiberales. J. Environ. Pathol. Toxicol. Oncol., 23: 227-236.
CrossRef  |  Direct Link  |  

Iqbal, M., S.D. Sharma, Y. Okazaki, M. Fujisawa and S. Okada, 2003. Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: Possible role in protection against chemical carcinogenesis and toxicity. Pharmacol. Toxicol., 92: 33-38.
CrossRef  |  PubMed  |  

Joshi, J., S. Ghaisas, A. Vaidya, R. Vaidya, D.V. Kamat, A.N. Bhagwat and S. Bhide, 2003. Early human safety study of turmeric oil (Curcuma longa oil) administered orally in healthy volunteers. J. Assoc. Physician India, 51: 1055-1060.
PubMed  |  Direct Link  |  

Krsek, M. and E.M.H. Wellington, 1999. Comparison of different methods for the isolation and purification of total community DNA from soil. J. Microb. Methods, 39: 1-16.
PubMed  |  Direct Link  |  

Kuo, M.L., T.S. Huang and J.K. Lin, 1996. Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells. Biochim. Biophys. Acta, 15: 95-100.
PubMed  |  Direct Link  |  

Lai, P.K. and J. Roy, 2004. Antimicrobial and chemopreventive properties of herbs and spices. Curr. Med. Chem., 11: 1451-1460.
CrossRef  |  PubMed  |  Direct Link  |  

Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.J. Randall, 1951. Protein measurement with the folin phenol reagent. J. Biol. Chem., 193: 265-275.
PubMed  |  Direct Link  |  

Odot, J., P. Albert, A. Carlier, M. Tarpin, J. Devy and C. Madoulet, 2004. In vitro and in vivo anti-tumoral effect of curcumin against melanoma cells. Int. J. Cancer, 111: 381-387.
PubMed  |  Direct Link  |  

Rajakumar, D.V. and M.N. Rao, 1994. Antioxidant properties of dehydrozingerone and curcumin in rat brain homogenates. Mol. Cell. Biochem., 140: 73-79.
CrossRef  |  Direct Link  |  

Ruby, A.J., G. Kuttan, K.D. Babu, K.N. Rajasekharan and R. Kuttan, 1995. Anti-tumour and antioxidant activity of natural curcuminoids. Cancer Lett., 94: 79-83.
PubMed  |  Direct Link  |  

Sharma, R.A., H.R. McLelland, K.A. Hill, C.R. Ireson and S.A. Euden et al., 2001. Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clin. Cancer Res., 7: 1894-1900.

Singh, S. and B.B. Aggarwal, 1995. Activation of transcription factor NF-κB is suppressed by curcumin (diferuloylmethane). J. Biol. Chem., 270: 24995-25000.
PubMed  |  Direct Link  |  

Somasundaram, S., N.A. Edmund, D.T. Moore, G.W. Small, Y. Shi and R.Z. Orlowski, 2002. Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer. Cancer Res., 62: 3868-3875.
PubMed  |  Direct Link  |  

Tang, W., 1992. Chinese Drugs of Plant Origin. Springer Verlag, Berlin, pp: 160-174.

Tegos, G., F.R. Stermitz, O. Lomovskaya and K. Lewis, 2002. Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials. Antimicrob. Agents Chemother., 46: 3133-3141.
CrossRef  |  Direct Link  |  

Venkatesan, N., 2000. Curcumin attenuation of acute adriamycin myocardial toxicity in rats. Br. J. Pharm., 124: 425-427.
CrossRef  |  

©  2019 Science Alert. All Rights Reserved
Fulltext PDF References Abstract