M. Demajo
Laboratory for Molecular Biology and Endocrinology,
Vinca Institute for Nuclear Sciences,
Belgrade, Yugoslavia
P. Plamenac
Mother and Child Health Institute, Department of Pathology, Belgrade, Yugoslavia
A. Karakasevic
Laboratory for Molecular Biology and Endocrinology,
Vinca Institute for Nuclear Sciences,
Belgrade, Yugoslavia
V. Pantic
Serbian Academy of Sciences and Arts, Belgrade, Yugoslavia
O. Ivanisevic- Milovanovic
Laboratory for Molecular Biology and Endocrinology,
Vinca Institute for Nuclear Sciences,
Belgrade, Yugoslavia
ABSTRACT
The findings of research work showed that animals with hyperluteinized ovaries (HL) obtained after mechanical lesions in the posterior hypothalamus, the circulatory patterns of pituitary and ovarian steroid hormones were disturbed. In these animals the pre-ovulatory surge of luteinizing hormone (LH) was lower and prolactin (Prl) was higher, while in early proestrus estradiol was higher, and progesterone in late proestrus was lower when compared to the intact controls. It is recognized that there is a close relationship between ovarian function and thyroid hormones, measured the serum content of total tri-iodothyronine (T3) and thyroxine (T4) in animals with hyperluteinized ovaries obtained after mechanical lesions in the posterior hypothalamus. There were no a significant differences in the circulatory concentrations of these hormones between rats with HL and intact controls. Histological analysis also showed that there were no significant differences in structure of thyroids between the two groups of animals, although the weights of the thyroid glands in the lesioned animals were significantly heavier than in intact controls. These results showed that lesions in the posterior hypothalamus, which result in a disturbance of the hypothalamo-pituitary-ovarian axis inducing HL, did not bring about changes in the hypothalamo-pituitary-thyroid axis.
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How to cite this article
M. Demajo, P. Plamenac, A. Karakasevic, V. Pantic and O. Ivanisevic- Milovanovic, 2001. Thyroid Hormones in Rats with Hyperluteinized Ovaries. Journal of Medical Sciences, 1: 113-116.
DOI: 10.3923/jms.2001.113.116
URL: https://scialert.net/abstract/?doi=jms.2001.113.116
DOI: 10.3923/jms.2001.113.116
URL: https://scialert.net/abstract/?doi=jms.2001.113.116
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