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Trends in Applied Sciences Research

Year: 2012 | Volume: 7 | Issue: 8 | Page No.: 596-619
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Authors

Rakesh Tiwle

Ajazuddin

Tapan Kumar Giri

Dulal Krishna Tripathi

Vishal Jain

Amit Alexander

Keywords

The combinatorial chemistry and high throughput screening increases the solubility of poorly water soluble compounds. The most challenging task in development of a formulation is the solubility of drug, availability at the site of action and stability of drug. Aqueous solubility of any therapeutically active substance is a key property as it governs dissolution, absorption and thus the in vivo efficacy. Among all newly discovered chemical entities about 40% drugs are lipophilic and these drugs are rejected by the pharmaceutical industry and will never benefit a patient because of its poor bioavailability due to low water solubility and/or cell membrane permeability. Drug efficacy can be severely limited by poor aqueous solubility and some drugs also show side effects due to their poor solubility. Therefore, drug release profiles are exhibited by such formulations for poorly soluble drugs to improve the solubility of such poorly soluble drugs. Any drug to be absorbed must be present in the form of an aqueous solution at the site of absorption. Water is the solvent of choice for liquid pharmaceutical formulations. Most of drugs which are weakly acidic and basic show poor aqueous solubility hence various methods like, salt formation, co-solvency, micronization, addition of agent, solid dispersion, complexation etc., are some of the vital approaches routinely employed to enhance the solubility of poorly soluble drugs. This article reviews various methods used for improving the solubility of hydrophobic drugs and improve the drug release profiles which are exhibited by such formulations for poorly soluble drugs.
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How to cite this article

Rakesh Tiwle, Ajazuddin, Tapan Kumar Giri, Dulal Krishna Tripathi, Vishal Jain and Amit Alexander, 2012. An Exhaustive Review on Solubility Enhancement for Hydrophobic Compounds by Possible Applications of Novel Techniques. Trends in Applied Sciences Research, 7: 596-619.

URL: https://scialert.net/abstract/?doi=tasr.2012.596.619

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