
	Research Journal of Medicinal Plants
	Year: 2012 \| Volume: 6 \| Issue: 8 \| Page No.: 607-614 DOI: 10.3923/rjmp.2012.607.614

Evaluation of Antinociceptive and Antioxidant Activities of Whole Plant Extract of Bacopa monniera

Subrata Kumar Biswas, Joysree Das, Anusua Chowdhury, Utpal Kumar Karmakar and Hemayet Hossain

Abstract: Bacopa monniera commonly known as Brahmi grows in Bangladesh. The objective of the present study was to investigate the antinociceptive and antioxidant activities of ethanol extract of the whole plant of (B. monniera). The antinociceptive potential of the plant was determined using acetic acid induced writhing method. The results showed 39.79% (p<0.05) inhibition of writhings in the experimental animals when the plant extract was given intraperitoneally (i.p.) at 250 mg kg^-1 b.wt. However, the extract produced maximum 56.14% (p<0.05) acetic acid induced writhing inhibition in mice at the dose of 500 mg kg^-1 b.wt. This was also found to be comparable to the standard drug, Diclofenac-Na at 25 mg kg^-1 b.wt. which inhibited 76.52% (p<0.05) of writhing reflex. The plant extract showed a dose dependent antinociceptive activity in acetic induced writhing model in mice. It was also found that the obtained p-values calculated by student’s t-test were statistically significant. In order to determine the antioxidant activity of B. monniera, the extract was also assessed by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging method. The plant extract showed significant DPPH free radical scavenging effect compared to the standard antioxidants such as ascorbic acid and Butylated Hydroxy Anisole (BHA). The IC₅₀values of the extract, ascorbic acid and BHA were 79.84, 9.45 and 14.15 μg mL^-1, respectively. Thus, the present study confirmed the antinociceptive and antioxidant activities of the ethanol extract of the whole plant of B. monniera. Finally, it is suggested to do further research for isolation and identification of the chemical structures of the phytochemical compounds responsible for antinociceptive and antioxidant activities of B. monniera.

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How to cite this article:

Subrata Kumar Biswas, Joysree Das, Anusua Chowdhury, Utpal Kumar Karmakar and Hemayet Hossain, 2012. Evaluation of Antinociceptive and Antioxidant Activities of Whole Plant Extract of Bacopa monniera. Research Journal of Medicinal Plants, 6: 607-614.

DOI: 10.3923/rjmp.2012.607.614

URL: https://scialert.net/abstract/?doi=rjmp.2012.607.614

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