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Research Journal of Botany
  Year: 2015 | Volume: 10 | Issue: 3 | Page No.: 98-103
DOI: 10.3923/rjb.2015.98.103
 
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Investigations of Analgesic Activity of the Methanol Extract of Haldina cordifolia (Roxb.) Bark by using in vivo Animal Model Studies

Md. Jakaria, Mohammad Parvez, Rashaduz Zaman, Arifujjaman , Md. Imran Hasan, Mohammed Abu Sayeed and Md. Hazrat Ali

Abstract:
The present study was to investigate the analgesic activity of the methanol extract of H. cordifolia bark by using in vivo animal model studies. The effect was studied using acetic acid-induced abdominal constriction test and formalin induced hind paw licking test in mice model. The results of the study showed that the extract exhibited significant analgesic effect. In acetic acid-induced writhing test, significant percentage of inhibition (78.48%) shows that at the dose of 400 mg kg–1 and at the same dose in formalin induced hand paw licking model shows significant activity in early phase (22.03% of inhibition) where in late phase (19.88% of inhibition) comparable to standard drug diclofenac sodium. These findings suggested that H. cordifolia bark has got the potential as a candidate for future analgesic agent.
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How to cite this article:

Md. Jakaria, Mohammad Parvez, Rashaduz Zaman, Arifujjaman , Md. Imran Hasan, Mohammed Abu Sayeed and Md. Hazrat Ali, 2015. Investigations of Analgesic Activity of the Methanol Extract of Haldina cordifolia (Roxb.) Bark by using in vivo Animal Model Studies. Research Journal of Botany, 10: 98-103.

DOI: 10.3923/rjb.2015.98.103

URL: https://scialert.net/abstract/?doi=rjb.2015.98.103

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