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Pakistan Journal of Biological Sciences

Year: 2024 | Volume: 27 | Issue: 3 | Page No.: 142-151
Research Article

Effectiveness of Gel from Andaliman Fruit (Zanthoxylum acanthopodium DC.) Extract on Wound Inflammation

Elsa Izza Sabila
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Indonesia
Annisa Ayu Ramadhani
Department of Agribusiness, Faculty of Agriculture, Universitas Sumatera Utara, Medan, Indonesia
Hanif Fadhilah
Department of Industrial Engineering, Faculty of Engineering, Universitas Sumatera Utara, Medan, Indonesia
Balqis Nur Nasution
Department of Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
Fathiya
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Indonesia
Putri Cahaya Situmorang
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Indonesia
LiveDNA: 62.30479
ORCID: 0000-0002-9895-1853
Background and Objective: Pain is caused by damaged tissue on the outside or inside of an organ and it is regulated by chemicals. Synthetic drugs are used to ease pain because they are analgesics in the field of medicine. Traditional medicine is known to help people all over the world, in both rich and developing nations. The Andaliman fruit, or Zanthoxylum acanthopodium DC., comes from a spice plant that grows naturally in Toba Regency, North Sumatra, Indonesia. This study aims to determine the formulation of the nanoherbal analgesic spray gel preparation of Andaliman fruit (Zanthoxylum acanthopodium DC.) in terms of its effectiveness as a pain reliever. Materials and Methods: There were three amounts of spray gel made, namely 5, 10 and 15% and tests were done to see how well they worked. Staphylococcus aureus bacteria were used in the bacterial blocking test. To test how well painkillers worked, five groups of mice were used. Using a hot iron, tests for anti-inflammatory activity and wound healing were done. The tissue was then watched for 14 days and analysed using Hematoxylin and Eosin (H&E) stains. Results: The 15% concentration reduces pain and the time it takes for the body to respond to it. The clear zone size is the same as (K+) and it can lower the number of inflammatory cells and help wounds heal by adding fibroblast and collagen cells. These findings are supported by significant data results (p<0.05, p = 0.018). Conclusion: Finally, analgesic gel spray made from the Andaliman fruit at a 15% concentration can help with pain and also be antibacterial, reduce inflammation and help wounds heal.

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How to cite this article

Elsa Izza Sabila, Annisa Ayu Ramadhani, Hanif Fadhilah, Balqis Nur Nasution, Fathiya and Putri Cahaya Situmorang, 2024. Effectiveness of Gel from Andaliman Fruit (Zanthoxylum acanthopodium DC.) Extract on Wound Inflammation. Pakistan Journal of Biological Sciences, 27: 142-151.

DOI: 10.3923/pjbs.2024.142.151

URL: https://scialert.net/abstract/?doi=pjbs.2024.142.151

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