Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Pakistan Journal of Biological Sciences
  Year: 2012 | Volume: 15 | Issue: 7 | Page No.: 353-357
DOI: 10.3923/pjbs.2012.353.357
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Comparison of the Haemodynamic Effects of Pyrethroid Insecticide and Amodiaquine in Rats

W.A. Saka, R.E. Akhigbe, O.S. Oyekunle, O.O. Adedipe and O.A. Akinwande

Abstract:
Malaria infection is a common cause of morbidity and mortality especially in the tropics and subtropics. This has led to the increased prophylactic use of pyrethroid insecticides and/or Amodiaquine (Aq) to combat the parasitic protozoan infection. The aim of this study was to investigate the comparative haemodynamic effects of pyrethroid insecticide and amodiaquine in rats. Experimental rats were randomly allocated into seven groups of five rats in each. Groups 1, 2 and 3 were exposed to pyrethroid by inhalation for 1, 2 and 3 min, respectively, while groups 4, 5 and 6 were administered Aq per oral at 5, 10 and 15 mg kg-1 b.wt., respectively. Control rats were neither exposed to pyrethroid nor administered Aq. Pyrethroid insecticide led to reduced systolic, diastolic and mean arterial pressures, but increased pulse pressure. Aq treatment did not cause any significant variation in haemodynamic variables. Heart rate was comparable in all groups. Results from the study provide extended safety/toxicity profile for pyrethroid use and Aq treatment. Aq showed no cardiotoxic potential, while pyrethroids have hypotensive effect. It is thus recommended that exposure to pyrethroids should be minimized.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Effect of Angiotensin I-Converting Enzyme Inhibitor, Captopril, on Body Weight and Food and Water Consumption in Oral Contraceptive-Treated Rats
  •    Effects of Pyrethroid Insecticide Exposure on Haematological and Haemostatic Profiles in Rats
How to cite this article:

W.A. Saka, R.E. Akhigbe, O.S. Oyekunle, O.O. Adedipe and O.A. Akinwande, 2012. Comparison of the Haemodynamic Effects of Pyrethroid Insecticide and Amodiaquine in Rats. Pakistan Journal of Biological Sciences, 15: 353-357.

DOI: 10.3923/pjbs.2012.353.357

URL: https://scialert.net/abstract/?doi=pjbs.2012.353.357

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 
 

Curve Bottom