Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Journal of Pharmacology and Toxicology
  Year: 2012 | Volume: 7 | Issue: 1 | Page No.: 58-63
DOI: 10.3923/jpt.2012.58.63
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Effects of Sodium Dichromate on Haemato-biochemical Parameters in Wistar Rats

Priti D. Vihol, Jatin Patel, Rasesh D. Varia, Jignesh M. Patel, D.J. Ghodasara, B.P. Joshi and K.S. Prajapati

Abstract:
A sub-acute toxicity experiment was conducted on 50 wistar rats which were randomly divided in five groups (group I to V) with five males and five females in each group to observe the haemato-biochemical alterations induced by sodium dichromate. Rats of group I to IV were administered graded dose of sodium dichromate @ 0.625, 1.25, 2.5, 5 mg kg-1, respectively by oral gavage route for 28 days whereas, group V rats act as control. Highest dose of sodium dichromate reported to produce dullness, lethargy and diarrhea along with reduction in body weight and feed consumption. Significant decrease in hemoglobin, PCV, TEC, MCV and MCH values were observed while TLC values increased in group III and IV rats. Serum biochemical parameters viz AST, ALT, ALP and creatinine increased significantly while plasma total protein and albumin values were significantly decreased. In conclusion, hemato-biochemical picture reveals that dose rate up to 2.5 mg kg-1 of sodium dichromate was well tolerated and high dose (5 mg kg-1) of sodium dichromate has potential to produce abnormalities in protein absorption and synthesis and kidney function.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Estimating the Plasma and Serum Activity Levels of Aspartate Aminotransferase and Alanine Aminotransferase, in Live Animals Using Regression Model
  •    A Review on the Applications of Organic Trace Minerals in Pig Nutrition
  •    Dietary Inclusion of Organic Chromium on Production and Carcass Characteristics of Broilers
  •    Epigenetic Effects of Carcinogens
  •    Genotoxic Potential of Agricultural Soils of Amritsar
How to cite this article:

Priti D. Vihol, Jatin Patel, Rasesh D. Varia, Jignesh M. Patel, D.J. Ghodasara, B.P. Joshi and K.S. Prajapati, 2012. Effects of Sodium Dichromate on Haemato-biochemical Parameters in Wistar Rats. Journal of Pharmacology and Toxicology, 7: 58-63.

DOI: 10.3923/jpt.2012.58.63

URL: https://scialert.net/abstract/?doi=jpt.2012.58.63

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 

Curve Bottom