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Journal of Pharmacology and Toxicology
  Year: 2011 | Volume: 6 | Issue: 5 | Page No.: 541-547
DOI: 10.3923/jpt.2011.541.547
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Efficacy and Safety of Diclofenac Sodium and Aceclofenac in Controlling Post Extraction Dental Pain: A Randomised Open Label Comparative Study

Kudaravalli Jyothsna, Narayan Deshpande and Gali Vijayalakshmi

The aim of this study was to evaluate the efficacy and safety of newer drug Aceclofenac 100 mg BD compared to Diclofenac Sodium 50 mg three times daily tid in post extraction dental pain. A total number of 100 patients posted for third molar extraction were recruited for the study. Those who met the inclusion criteria (n = 51) were randomized into two treatment groups A and B. Group A received T. Diclofenac Sodium and Group B received T. Aceclofenac. On the day of surgery patients were given the study drugs and Visual Analog Scales (VAS) to assess the pain intensity for 5 days. Baseline pain intensity immediately after surgery and at 8 h was recorded on the day of surgery. On day 5 evaluated statistically using one way analysis of variance. The statistical analysis of pain intensity using VAS showed that 78% of patients showed severe baseline pain intensity and at the end of 8 h on the first day of surgery, Diclofenac group showed 27% reduction in pain intensity and 40% reduction in Aceclofenac group (p<0.05). On day 5 pain reduction was 95% and 100% in Diclofenac and Aceclofenac group, respectively. Global assessment and safety assessment showed better gastrointestinal profile for the Aceclofenac than Diclofenac sodium. It proves that Aceclofenac has a rapid onset and prolonged pain relief and statistically significant analgesic effect in the immediate postoperative period of 8 h in comparison to Diclofenac sodium.
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How to cite this article:

Kudaravalli Jyothsna, Narayan Deshpande and Gali Vijayalakshmi, 2011. Efficacy and Safety of Diclofenac Sodium and Aceclofenac in Controlling Post Extraction Dental Pain: A Randomised Open Label Comparative Study. Journal of Pharmacology and Toxicology, 6: 541-547.

DOI: 10.3923/jpt.2011.541.547






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