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Journal of Plant Sciences

Year: 2006 | Volume: 1 | Issue: 1 | Page No.: 80-85
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Authors

V. Prasad

V. Jain

A.K. Dorle

Keywords

Research Article

Evaluation of Momordica charantia ghrita for Immunomodulatory Activity

V. Prasad, V. Jain and A.K. Dorle
Momordica charantia ghrita contains cow’s ghee and Momordica charantia, as its main constituents and rock salt. In the present study an attempt has been made to evaluate Momordica charantia ghrita for immunomodulatory activity. MG was administered orally at doses of 175 and 350 mg/kg/day to healthy rats. Assessment of immunomodulatory activity was carried out by testing the humoral (antibody titre) and cellular (foot pad swelling) immune responses to the antigenic challenges with sheep RBCs and by neutrophil adhesion test. Orally administered MG showed a significant increase of test parameters viz., neutrophil test, Haemagglutinating Antibody Ttitre (HAT) and Delayed Type Hypersensitivity (DTH) response. In rats immunized with sheep RBC, MG enhanced the humoral antibody response to the antigen and significantly potentiated the cellular immunity by facilitating the foot pad thickness response to sheep RBC in sensitized rats. There was dose dependent increase in immunomodulation, there was significant improvement compared to control group and the differences were statistically significant in 350 mg/kg/day, therefore Momordica charantia ghrita promises strong utility in clinical practice as an effective immunostimulant.
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