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Asian Journal of Biological Sciences
  Year: 2019 | Volume: 12 | Issue: 2 | Page No.: 173-179
DOI: 10.3923/ajbs.2019.173.179
 
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Prevention of Hypertension and Arterial Stiffness by Combination of Centella asiatica and Curcuma longa in Rats

Patonah Hasimun , Yani Mulyani, Agus Sulaeman and Dewa Ayu Embas Saraswati

Abstract:
Background and Objectives: Hypertension is characterized by an increase in systolic and or diastolic blood pressure. Arterial stiffness is an independent cardiovascular risk factor in hypertensive patients. Increasing arterial stiffness correlates with hypertension progression. This study aimed to determine anti-hypertensive activity and reducing arterial stiffness, combination of Centella asiatica and Curcuma longa, in 25% fructose-induced hypertensive animal models in drinking water and high-fat diet. Materials and Methods: This study was conducted on male Wistar rats with 3 methods: Diuretic test, anti-hypertensive test and arterial stiffness test by non-invasive method. Two doses combination of Centella asiatica and Curcuma longa were at 3.6 and 1.8 g kg1 in juice preparation, compared to furosemide (diuretic test), captopril (anti-hypertensive test). Parameters measured were urine volume, systolic and diastolic blood pressure and Pulse Wave Velocity (PWV). Results: Combination of Centella asiatica and Curcuma longa in juice preparation, increased urine output (diuretic), decreased systolic and diastolic blood pressure and improved arterial stiffness (p<0.05) compared to the control group. Conclusion: Combination of Centella asiatica and Curcuma longa in juice preparation has anti-hypertensive activity and improved arterial stiffness.
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How to cite this article:

Patonah Hasimun, Yani Mulyani, Agus Sulaeman and Dewa Ayu Embas Saraswati, 2019. Prevention of Hypertension and Arterial Stiffness by Combination of Centella asiatica and Curcuma longa in Rats. Asian Journal of Biological Sciences, 12: 173-179.

DOI: 10.3923/ajbs.2019.173.179

URL: https://scialert.net/abstract/?doi=ajbs.2019.173.179

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