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Asian Journal of Biochemistry

Year: 2012 | Volume: 7 | Issue: 4 | Page No.: 232-236
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Authors

Mohammadreza Valilou

Alireza Lotfi

Keywords

Short Communication

Changes in Body Weight and Serum Biochemical Measures of German Shepherd Dogs following Alloxan Induced Diabetes Mellitus

Mohammadreza Valilou and Alireza Lotfi
The body weight losses and serum biochemical indices are considered as major signs of diabetes mellitus. The aim of present research was to investigate possible changes in serum biochemical indices and live body weight in German shepherd dogs, as a laboratory model for diabetes studies. In this research, ten German shepherd dogs has been used for analysis; 5 of which was considered as experimental groups and 5 was considered as control group. The examinations were conducted to guarantee their health and absence of diabetes with Intra-venous Glucose Tolerance Test (IVGTT) has been approved. Alloxan monohydrate with 100 mg kg-1 in was injected intravenously for experimental group. After weighting, the blood samples were taken from control and diabetic dogs following diabetes induction. Next, biochemical measures of serum measures include glucose, total cholesterol, triglyceride, creatinine, total protein concentrations, Alanine Transaminase (ALT), Aspartate Transaminase (AST) and Alkaline Phosphatase (ALP) activity were determined. Based on statistical analysis, regardless to dramatic increases in glucose level, ALT and AST activities are increased in diabetic groups (p<0.05) and observed increase in serum ALP activity was very significant (p<0.01). The body weight of control group had almost constant trend during experiment, but diabetic dogs had considerable weigh losses especially after second IVGGT and following diabetes induction. It can be concluded that the weight losing of diabetic individual may be largely Independent from serum total cholesterol or triglyceride concentrations and is related to protein metabolism, because of lack of glucose source for energy obtaining. Further studies with completive biochemical profile of plasma are needed to clarifying discussed correlations.
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