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Articles by Ping Wang
Total Records ( 9 ) for Ping Wang
  Weiren Yang , Ping Wang , Yuanqiang Jing , Zaibin Yang , Chongyu Zhang , Shuzhen Jiang and Guiguo Zhang
  Problem statement: It is regarded that vitamin A protects cells from damage by radicals which are believed to contribute to certain chronic diseases and regulates immune function of animals by protection of mucosal epithelium acting as the first defense barrier. All these properties of vitamin A may be attributable to its antioxidant activity. This study was to evaluate the effects of different levels of vitamin A on growth performance, antioxidant status and blood constituents of lactating ewes. Approach: Thirty-two multiparous lactating ewes of Grey goat (BW = 35.1 ± 1.1 kg) were divided into four groups of eight with four different supplementing levels of vitamin A (0, 2000, 3000 and 5000 IU kg-1 DM). Ewes were fed in individual lot at ad libitum intake and had free access to water. Average daily feed intake and average milk yield of ewes were measured weekly. Blood was obtained every 14 days to evaluate activities of antioxidant enzymes, blood constituents and vitamin A levels in serum. Results: In general, feed intake, milk yield and feed efficiency were not affected by vitamin A supplementation. However, supplementation of vitamin A increased (p<0.05) activities of glutathione peroxidase and total antioxidant capacity, but reduced (p<0.05) concentrations of malondialdehyde in serum of ewes. Red cells number increased linearly (p<0.01) and quadraticly (p<0.01) with incremental amount of vitamin A. Number of lymphocyte, concentration of hemoglobin and haematocrit were increased (p<0.05) by supplementing vitamin A. Serum retinol concentration was higher (p<0.05) for ewes supplemented with vitamin A at 5000 IU kg-1 than for control ewes, but retinol concentration in milk was not difference (p>0.05) among treatments. Conclusion/Recommendations: Addition of vitamin A improved antioxidant status of lactating Grey goat thereby enhanced their immune function. The optimum level of vitamin A supplementation for this purpose was between 2000 and 3000 IU kg-1 DM.

  Gui Shen , Yan- Li Wang , Amy Whittington , Lie Li and Ping Wang
  Crg1 and Crg2 are regulators of G-protein signaling homologs found in the human fungal pathogen Cryptococcus neoformans. Crg1 negatively regulates pheromone responses and mating through direct inhibition of Gα subunits Gpa2 and Gpa3. It has also been proposed that Crg2 has a role in mating, as genetic crosses involving Δcrg2 mutants resulted in formation of hyperfilaments. We found that mutation of Gpa2 and Gpa3 partially suppressed the hyperfilamentation, mutation of Gpa3 alleviated Δcrg2-specfic cell swelling, and mutation of the mitogen-activated protein kinase Cpk1 blocked both processes. These findings indicate that Gpa2 and Gpa3 function downstream of Crg2 and that Gpa3 is also epistatic to Crg2 in a Cpk1-dependent morphogenesis process linked to mating. Significantly, we found that Δcrg2 mutants formed enlarged capsules that mimic cells expressing a constitutively active GPA1(Q284L) allele and that the levels of intracellular cyclic AMP (cAMP) were also elevated, suggesting that Crg2 also negatively regulates the Gpa1-cAMP signaling pathway. We further showed that Crg2 interacted with Gpa3 and Gpa1, but not Gpa2, in a pulldown assay and that Crg2 maintained a higher in vitro GTPase-activating protein activity toward Gpa3 and Gpa1 than to Gpa2. Finally, we found that dysregulation of cAMP due to the Crg2 mutation attenuated virulence in a murine model of cryptococcosis. Taken together, our study reveals Crg2 as an RGS (regulator of G-protein signaling) protein of multiregulatory function, including one that controls mating distinctly from Crg1 and one that serves as a novel inhibitor of Gpa1-cAMP signaling.
  Kevin T. Militello , Ping Wang , Sangeeta K. Jayakar , Rebecca L. Pietrasik , Christopher D. Dupont , Kristi Dodd , Anthony M. King and Paul R. Valenti
  It is currently unclear if there are modified DNA bases in Trypanosoma brucei other than J-base. We identify herein a cytosine-5 DNA methyltransferase gene and report the presence and location of 5-methylcytosine in genomic DNA. Our data demonstrate that African trypanosomes contain a functional cytosine DNA methylation pathway.
  Chun-Xiang Wang , Zhi-Feng Li , Chen-Xia Du and Ping Wang
  A tetradentate N-donor ligand 1,4-bis[2-(2-pyridyl)benzimidazolato]butane (L) was prepared for construction of a coordination framework. Three one-dimensional coordination polymers lcub[M(II)L(NCS)2](DMF)2rcubn (M(II) = cadmium(II), 1, zinc(II), 2, manganese(II), 3) were obtained by reaction of metal ions and L in the presence of KSCN in DMF/water. The complexes are isostructural and consist of 1D zigzag [M(II)L(NCS)2]n chains and DMF molecules. Within the chains, the metal atoms are each octahedrally coordinated by four N atoms of L and two N atoms of the SCN- anions. Complexes 1 and 2 in the solid state at room temperature exhibit intense photoluminescence at 453 and 433 nm, respectively.
  Rui-Qing Fan , Hong Chen , Ping Wang , Yu-Lin Yang , Yan-Bing Yin and Wuliji Hasi
  Six 5-coordinate 2,6-bis(imino)pyridine metal complexes, [2,6-(ArN=CMe)2C5H3NMCl2 · nCH3CN] (Ar = 4-MeC6H4, M = Zn, n = 0.5, Zn1, M = Cd, n = 1, Cd1; Ar = 2,6-Et2C6H3, M = Zn, n = 0.5, Zn2, M = Cd, n = 0.5, Cd2; Ar = 2,4,6-Me3C6H2, M = Zn, n = 1, Zn3, M = Cd, n = 1, Cd3), were synthesized in acetonitrile by the reactions of the corresponding bis(imino)pyridines with ZnCl2 or CdCl2 · 2.5H2O, respectively. The structures of Zn1-Zn3 and Cd1-Cd3 were determined by the single-crystal X-ray diffraction. In all complexes, the ligand is tridentate with further coordination by two chlorides, resulting in a distorted trigonal bipyramid. All complexes self-assemble through hydrogen bonding interactions to form a 3-D supramolecular structure. At 298 K in dichloromethane, all complexes have blue luminescent emissions at 405-465 nm, which can be attributed to ligand-centered π* → π transitions. The zinc and cadmium centers play a key role in enhancing fluorescent emission of the ligands.
  Qingzhong Kong , Mengjie Zheng , Cristina Casalone , Liuting Qing , Shenghai Huang , Bikram Chakraborty , Ping Wang , Fusong Chen , Ignazio Cali , Cristiano Corona , Francesca Martucci , Barbara Iulini , Pierluigi Acutis , Lan Wang , Jingjing Liang , Meiling Wang , Xinyi Li , Salvatore Monaco , Gianluigi Zanusso , Wen -Quan Zou , Maria Caramelli and Pierluigi Gambetti
  Bovine spongiform encephalopathy (BSE), the prion disease in cattle, was widely believed to be caused by only one strain, BSE-C. BSE-C causes the fatal prion disease named new variant Creutzfeldt-Jacob disease in humans. Two atypical BSE strains, bovine amyloidotic spongiform encephalopathy (BASE, also named BSE-L) and BSE-H, have been discovered in several countries since 2004; their transmissibility and phenotypes in humans are unknown. We investigated the infectivity and human phenotype of BASE strains by inoculating transgenic (Tg) mice expressing the human prion protein with brain homogenates from two BASE strain-infected cattle. Sixty percent of the inoculated Tg mice became infected after 20 to 22 months of incubation, a transmission rate higher than those reported for BSE-C. A quarter of BASE strain-infected Tg mice, but none of the Tg mice infected with prions causing a sporadic human prion disease, showed the presence of pathogenic prion protein isoforms in the spleen, indicating that the BASE prion is intrinsically lymphotropic. The pathological prion protein isoforms in BASE strain-infected humanized Tg mouse brains are different from those from the original cattle BASE or sporadic human prion disease. Minimal brain spongiosis and long incubation times are observed for the BASE strain-infected Tg mice. These results suggest that in humans, the BASE strain is a more virulent BSE strain and likely lymphotropic.
  Zhizhen Zhang , Stacy Ownby , Ping Wang , Wei Yuan , Wanli Zhang and Shiyou Li
  Chemical investigation on the whole plants of Liatris elegans resulted in the isolation and identification of the new ferulic acid ester (1) and arylnaphthalene lignan (2), together with 13 known compounds. The structures of the new compounds were established as p-hydroxyphenylferulate (1) and 5,3'-dihydroxy-4,4'-dimethoxy-2,7'-cycloligna-7,7'-diene-9,9'-lactone (2) by extensive NMR and HRESIMS spectroscopic analyses.
  Liang Peng , Qidong Zhao , Dejun Wang , Jiali Zhai , Ping Wang , Shan Pang and Shan Pang
  Zinc oxide nanorods were synthesized using a simple hydrothermal method. Formaldehyde-sensing characteristics were investigated without and with ultraviolet (UV) light irradiation. The gas response of nanorods to 110 ppm formaldehyde with UV light irradiation was about 120 times higher than that without UV light irradiation. The detection limit was as low as 1.8 ppm at room temperature. This high gas response under the UV light is attributed to photocatalytic oxidation. Furthermore, the significant improvements of the selectivity and recovery time were obtained after irradiating the nanorods with UV light. Our results demonstrated that applying UV light irradiation on the zinc oxide nanorods is an effective approach to achieve higher response and excellent selectivity to formaldehyde at room temperature.
  Peihua Chen , Xiao-dong Liu , Bingqing Wang , Gong Cheng and Ping Wang
  Taste receptor cell, the taste sensation organ with its intrinsic advantage of high sensitivity, specificity, fast response and powerful ability of information processing from taste system, can recognize taste substances. In order to investigate the electrophysiological signals of taste receptor cells and realize acidic sensation in a biomimetic manner, a cell-based biosensor platform of neuron–silicon interface was designed and characterized. Acid-sensing taste receptor cells were cultured on light-addressable potentiometric sensor (LAPS) to recognize sour stimuli as compared with non-acid solutions. A computational model of acid-sensing taste receptor cells was constructed to simulate the action potentials of taste receptor cells and to help decode the extracellular signals recorded by LAPS. The temporal firing and characteristic features from LAPS recordings upon acidic solutions demonstrate that this kind of hybrid biosensor based on taste receptor cells and LAPS can realize acidic sensation. This study also provides a prototype of a novel biosensor which deploys the sensory transduction and decoding mechanism from biology to realize chemosensing, potentially in a non-invasive and long-term manner.
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