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Eukaryotic Cell
Year: 2008  |  Volume: 7  |  Issue: 11  |  Page No.: 2012 - 2016

African Trypanosomes Contain 5-Methylcytosine in Nuclear DNA

Kevin T. Militello, Ping Wang, Sangeeta K. Jayakar, Rebecca L. Pietrasik, Christopher D. Dupont, Kristi Dodd, Anthony M. King and Paul R. Valenti    

Abstract: It is currently unclear if there are modified DNA bases in Trypanosoma brucei other than J-base. We identify herein a cytosine-5 DNA methyltransferase gene and report the presence and location of 5-methylcytosine in genomic DNA. Our data demonstrate that African trypanosomes contain a functional cytosine DNA methylation pathway.

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