Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Sensors and Actuators B: Chemical
Year: 2009  |  Volume: 139  |  Issue: 2  |  Page No.: 576 - 583

A biomimetic taste receptor cell-based biosensor for electrophysiology recording and acidic sensation

Peihua Chen, Xiao-dong Liu, Bingqing Wang, Gong Cheng and Ping Wang    

Abstract: Taste receptor cell, the taste sensation organ with its intrinsic advantage of high sensitivity, specificity, fast response and powerful ability of information processing from taste system, can recognize taste substances. In order to investigate the electrophysiological signals of taste receptor cells and realize acidic sensation in a biomimetic manner, a cell-based biosensor platform of neuron–silicon interface was designed and characterized. Acid-sensing taste receptor cells were cultured on light-addressable potentiometric sensor (LAPS) to recognize sour stimuli as compared with non-acid solutions. A computational model of acid-sensing taste receptor cells was constructed to simulate the action potentials of taste receptor cells and to help decode the extracellular signals recorded by LAPS. The temporal firing and characteristic features from LAPS recordings upon acidic solutions demonstrate that this kind of hybrid biosensor based on taste receptor cells and LAPS can realize acidic sensation. This study also provides a prototype of a novel biosensor which deploys the sensory transduction and decoding mechanism from biology to realize chemosensing, potentially in a non-invasive and long-term manner.

View Fulltext    |   Related Articles   |   Back
   
 
 
 
  Related Articles

No Article Found
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility