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Articles by Abu Sayeed
Total Records ( 10 ) for Abu Sayeed
  A.K.M. Nasimul Islam , M. Abbas Ali , Abu Sayeed , Syed M. Abdus Salam , Anwarul Islam , Motiur Rahman , G.R.M. Astaq Mohal Khan and Seatara Khatun
  A terpenoid, 3-oxo-(20S, 24S)-epoxydammarane-19,25-diacetate (CP-1) isolated from the chloroform extract of barks of Caesalpinia pulcherrima was characterized on the basis of spectral data coupled with chemical evidence. The compound showed significant antibacterial activity against a number of pathogenic bacteria and prominent antifungal activity against a few fungi. The minimum inhibitory concentration (MIC) values against Bacillus cereus and Shigella dysenteriae were 16 μg ml-1 and 32 μg ml-1 respectively. The compound was found cytotoxic against brine shrimp and LC50 value was 8.41 μg ml-1. These findings suggested for further clinical trial.
  Kawsar Uddin , Abu Sayeed , Anwarul Islam , Aziz Abdur Rahman , Abbas Ali , G.R.M. Astaq Mohal Khan and Md. Golam Sadik
  Phytochemical examination of the ethyl acetate extract of root parts of Oroxylum indicum Vent. has led to the isolation of two flavonoid: 2,5-dihydroxy-6,7-dimethoxy flavone and 3,7,3’,5’-tetramethoxy-4-hydroxy flavone by a combination of column and preparative thin layer Chromatography. The structure of these compounds were determined by spectroscopic analysis as well as by comparison of their spectral data with previously reported values. The cytotoxicity of these two compounds and crude petroleum ether, ethyl acetate and methanol extracts was done by brine shrimp lethality bioassay. The LC50 values of compound 1 and 2 and petroleum ether, ethyl acetate and methanol extracts were found to be 14.12, 3.80, 3.97, 6.02 and 8.70 μg/ml, respectively.
  Atiqur Rahaman , Abu Sayeed , Anwarul Islam , Dulaly Chowdhury , Golam Sadik and G. R. M. Astaq Mohal Khan
  A triterpenoid, Bet-20(29)-en-3-ol-28-oic acid (1) was isolated from the ethyl acetate extract of Nymphoides cristatum (Roxb.) O.kuntze and its structure was elucidated on the basis of spectral evidences. This is the first report of isolation of this compound from this plant. The compound was screened for antimicrobial activity against a number of pathogenic bacteria and fungi and the cytotoxic activity by brine shrimp lethality bioassay. The test agent exhibited significant antimicrobial activity against most of the bacteria and fungi. The minimum inhibitory concentration (MIC) of the test agent determined against Bacillus cereus, Bacillus subtilis, Escherichia coli and Shigella sonnei was found to be 64, 128, 64 and 32 μg/ml respectively. The compound also showed prominent cytotoxic activity. The LC50 (median lethal concentration) was 15.39 μg/ml. 50.
  Kawsar Uddin , Abu Sayeed , Anwarul Islam , Aziz Abdur Rahman , Seatara Khatun , G.R.M. Astaq Mohal Khan and Md. Golam Sadik
  The chromatographic examination of the ethyl acetate extract of a local plant Oroxylum indicum Vent. (Family: Bignoniaceae) has led to the isolation of two flavonoids: 2,5-dihydroxy-6,7-dimethoxy flavone (Compound 1) and 3, 7, 3`, 5`-tetramethoxy-4`-hydroxy flavone (Compound 2). The in vitro anti microbial activity of crude petroleum ether, ethyl acetate and methanol extracts and compound 1 and 2 was screened against fourteen (five Gram-positive and nine Gram-negative) pathogenic bacteria and seven pathogenic fungi using the disk diffusion method. The zones of inhibition produced by the crude petroleum ether, ethyl acetate and methanol extracts and compound 1 and 2 against pathogenic bacteria were found between 8-16, 8-19, 0-8, 9-18 and 9-21 mm, respectively and against pathogenic fungi, 8-20, 8-18, 9-15, 9-20 and 7-18 mm, respectively. The crude petroleum ether and ethyl acetate extracts and compound 1 and 2 showed mild to moderate activity against all bacteria and fungi, whereas the methanol extract showed little activity against bacteria but moderate activity against fungi. The minimum inhibitory concentration (MIC) of the compound 1 and 2 were measured against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Shigella dysenteriae and the values were found to be between 64-128 μg/ml.
  Anwarul Islam , Abu Sayeed , Nurul Absar and Md. Ibrahim H. Mondal
  An experiment was conducted to find out the enzymatic change in jute leaves under different foliar treatments in the experimental land of the Institute of Biological Sciences, Rajshahi University during the period of April-May, 2000-2001. The effect of NPK-fertilizers and cowdung as well as foliar spray of urea and chemicals on the changes in the enzyme contents of matured jute leaves was analyzed. It was found that the activities of all the experimental enzymes in the leaves from treated jute plants were increased significantly as compared to those in control ones. Of the enzymes examined, the activities of protease were found to be increased highest (93.33%), followed by cellulase (88.57%), invertase (87.50%) and so on in decreasing order.
  Anwarul Islam , Abu Sayeed , Nurul Absar , Md. Ibrahim H. Mondal and Shamsul Alam
  The experiment was performed in the experimental land of the Institute of Biological Sciences, Rajshahi during the period of April-May, 2000 and 2001. The physicochemical compositions of jute leaves under different foliar treatments were investigated at the mature stage. The results obtained showed significantly increase in most of the chemical composition under different treatments. The soil of the cultivated land as well as jute leaves obtained from experimental land became less acidic as compared to those of control field after application of NPK-fertilizers and cowdung in combination with foliar spray. The highest percentage of increase of jute plant and physico-chemical composition of leaves as compared to those of control were as follows: length of jute plant 38.35%, area of jute leaf 160.00%, specific gravity 6.48%, dry matter 27.78%, ash content 18.55%, total chlorophyll 42.17%, total sugar 69.47%, reducing sugar 48.15%, non-reducing sugar 72.90%. Only the moisture content of jute leaves from control jute plant was about to higher as compared to that from experimental jute leaves.
  Anwarul Islam , Abu Sayeed , Md. Anwar-Ul Islam , G. R. M. Astaq Mohal Khan , M. Helal U. Biswas and M. Shah Alam Bhuiyan
  The research work was conducted to investigate the antimicrobial and cytotoxic evaluation of a flavonone. The flavonone, 5-methoxy-7-hydroxy flavonone (1), has been isolated from the leaves extract of Zanthoxylum budrunga and its structure was established on the basis of structural evidence. This is the first report of its occurrence from the plant. The compound (1) showed significant antimicrobial activity against a number of pathogenic bacteria and fungi. The minimum inhibitory concentration (MIC) of the compound (1) was found to be 16μg ml‾1 against Staphylococcus aureus. The compound showed prominent cytotoxic activity the LC50 and LC90 values of the compound (1) were found to be 16.24 and 56.56μg ml‾1, respectively.
  Farque Ahmed , Abu Sayeed , Anwarul Islam , S. M. Abdus Salam , Golam Sadik and G. R. M. Astaq Mohal Khan
  The ethyl acetate (C2H5COOCH3) extract of the roots of Vanda roxburghii Br. is known to have a significant antimicrobial activity. The investigation was carried out on the C2H5COOCH3 extract for the isolation and characterization of the active principle (s). The extract afforded a glycoside, 17-β-hydroxy-14, 20-epoxy-1-oxo- [22R]-3β-[O-β-D-glucopyranosyl]-5,24-withadienolide (VR-2), the structure of which was elucidated on the basis of spectral evidences. Compound VR-2 was screened against a wide variety of pathogenic bacteria and fungus for its antimicrobial activity by disc diffusion method. The compound showed significant antibacterial activity against most of the tested strain of bacteria and produced zone of inhibition between 14 to 28mm. The compound also showed significant antifungal activity and the minimum inhibitory concentration (MIC) of VR-2 against Bacillus cereus, Bacillus subtilis, Escherichia coli, Shigella dysenteriae and pseudomonus aeruginosa was determined and the values were 8, 32, 16, 8 and 16μg ml-1, respectively.
  Anwarul Islam , Abu Sayeed , Golam Sadik , M. Motiur Rahman and G. R. M. Astaq Mohal Khan
  Two clerodane diterpines viz., Kolavenic acid (1) and 16-oxo-cleroda-3, 13(14) E-diene-15-oic acid (2) were isolated from the petroleum ether (C2H5-O-C2H5) extract of the seed of Polyalthia longifolia and were screened against fourteen pathogenic bacteria for their antibacterial activities. The test materials exhibited strong activities against most of the test bacteria. The minimum inhibitory concentration (MIC) of the compound (1) and (2) was determined against Bacillus cereus, Bacillus subtilis, Escherichia coli, Shigella flexneriae and Shigella boydii which were 64, 64, 32, 16 and 32μg ml-1 for compound (1) and 16, 32, 8, 4 and 16 μg ml-1 for compound (2), respectively. The cytotoxic activity of the compound (1) and (2) was determined by brine shrimp lethality bioassay. Both the compounds showed significant cytotoxic activities and LC50 values of Kolavenic acid (1) and 16-oxo-cleroda-3, 13(14)E-diene-15-oic acid (2) were 3.16 and 2.52μg ml-1, respectively.
  Anwarul Islam , Abu Sayeed , M. Shah Alam Bhuiyan , M. Ashik Mosaddik G. , R. M. Astaq Mohal , M. A. Rashid and Md. Anwar-UI Islam
  Three terpenes lup-20 (29)-en-3-one (ZB-1), 11 , 13-dihydro-1epireynosin (ZB-2) and tetracyclic diterpenol-15-cinnamate (ZB-3) were isolated from the bark of the plant Zanthoxylum budrunga and were screened against some pathogenic bacteria and fungi. They were found significant in vitro antibacterial and antifungal. The zones of inhibition produced by the pure compounds were laid between 9 mm to 23 mm. The MIC values of the three isolated compounds were also determined against four test organisms (107 cells/ml) and were found to be effective between 16 μg/ml to 128 μg/ml.
 
 
 
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